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Odor identification deficit as a predictor of five-year global cognitive change: Interactive effects with age and ApoE-ε4
Umeå University, Faculty of Social Sciences, Department of Psychology. (Department of Psychology, Stockholm University, 10691 Stockholm, Sweden and Stockholm Brain Institute, Stockholm, Sweden)
Umeå University, Faculty of Social Sciences, Department of Psychology. (Centre for Population Studies, Umeå University, Umeå, Sweden)
Umeå University, Faculty of Social Sciences, Department of Psychology. (Department of Psychology, San Diego State University, San Diego, CA, USA)
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
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2009 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 39, no 5, 496-503 p.Article in journal (Refereed) Published
Abstract [en]

Olfactory impairments are present in common neurodegenerative disorders and predict conversion to dementia in non-demented individuals with cognitive impairment. In cognitively intact elderly, evidence is sparse regarding the role of olfactory deficits in predicting cognitive impairment. The present study investigated predictors of 5-year prospective decline in the Mini-Mental State Examination (MMSE) in a large (n = 501), population-based sample of elderly (65-90 years) individuals. All participants were genotyped for the ApoE gene, assessed for health factors, and were non-demented at the baseline assessment. After partialling out the influences of demographic and health-factors at baseline and dementia at follow-up, poor odor identification ability in combination with older age and the ApoE-epsilon4 allele predicted larger prospective global cognitive decline. This effect could not be produced by a vocabulary test. In sum, the findings suggest that an olfactory deficit can dissociate between benign and malign global cognitive development in non-demented, very old epsilon4-carriers, who are at high risk of developing dementia.

Place, publisher, year, edition, pages
Springer , 2009. Vol. 39, no 5, 496-503 p.
Keyword [en]
ApoE, Odor identification, Olfaction, Aging, Dementia
National Category
Research subject
URN: urn:nbn:se:umu:diva-3451DOI: 10.1007/s10519-009-9289-5PubMedID: 19633944OAI: diva2:142152
Available from: 2008-09-18 Created: 2008-09-18 Last updated: 2011-06-07Bibliographically approved
In thesis
1. Odor identification in aging and dementia: Influences of cognition and the ApoE gene
Open this publication in new window or tab >>Odor identification in aging and dementia: Influences of cognition and the ApoE gene
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Olfactory function is impaired in aging and dementia. The general aim of this thesis was to identify variables that predict olfactory function and dysfunction (assessed with an odor identification test) in middle-aged and elderly adults. The thesis investigated whether odor identification performance was associated with demographic variables, cognitive function, the ApoE gene, dementia, and other health-related variables. The ApoE-ε4 allele is associated with cognitive impairment and Alzheimer’s disease, the most common form of dementia. The studies included in this thesis used data from the Betula study, a large-scale, population-based prospective study on aging, memory, and health. Study 1 investigated demographic and cognitive predictors of odor identification ability in non-demented participants. The results showed that younger age, female sex, and high education contributed to better odor identification ability. Cognitive speed and vocabulary had a small additional influence. Study 2 included information about ApoE genotypes, dementia and other health-related variables. The results indicated that the ApoE-ε4 allele was associated with odor identification impairment among the elderly, but not middle-aged adults. Participants who were demented at the time of testing or became demented within five years after testing exhibited olfactory impairments. Interestingly, the age-related olfactory impairment in ε4-carriers was independent of clinical dementia within five years. In Study 3, decline in global cognitive status over a five-year test-retest interval was predicted in a sample of elderly participants. The major result was a three-way interaction reflecting that odor identification impairment, old age, in combination with the ε4 allele predicted a larger cognitive decline. However, odor identification impairment did not predict cognitive change in elderly who were non-carriers of the ε4 allele. Overall, the results indicate that odor identification impairment in elderly is related to ApoE-ε4, cognitive decline, and clinical and pre-clinical stages of dementia. Theoretical and practical implications of the results are discussed. Furthermore, it is proposed that in order to effectively predict clinical dementia or cognitive decline from olfactory assessment in the elderly, variables that mediate (e.g. neuropathology) or moderate (e.g. age) the associations between olfactory function, the ε4 allele, and dementia need to be further evaluated, preferably in studies using longitudinal assessment.

Place, publisher, year, edition, pages
Umeå: Psykologi, 2008. 91 p.
Aging, olfaction, identification, dementia, Alzheimer, genetics, ApoE, population based, cognition, demographics
National Category
urn:nbn:se:umu:diva-1835 (URN)9789172646520 (ISBN)
Public defence
2008-10-10, Hörsal D, Samhällsvetarhuset, Umeå Universitet, Umeå, 10:15
Available from: 2008-09-18 Created: 2008-09-18Bibliographically approved

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Olofsson, JonasMichael, RönnlundNordin, StevenNyberg, Lars
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