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Postprandial responses of glucose, insulin and triglycerides: influence of the timing of meal intake during night work
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational Medicine.
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2002 (English)In: Nutrition and health, ISSN 0260-1060, Vol. 16, no 2, 133-141 p.Article in journal (Refereed) Published
Abstract [en]

The objective was to study the postprandial responses of glucose, insulin and triglycerides to meal intake at different clock times during night work. Eleven night shift working nurses participated. Identical test meals were ingested at 19:30, 23:30 and 03:30, and contained 440 kcal/1,860 kJ of energy (33 E% fat, 51 E% carbohydrate, 16 E% protein). The food intake was standardized three days before the first test meal. Blood samples were drawn just before the test meals were ingested and thereafter at 30, 60, 90, 120, 180 and 240 minutes. The postprandial responses were estimated as the total area under the curve (AUC) and significance testing was done using repeated measures ANOVA. The highest insulin level was found after meal intake at 23:30, and the lowest after meal intake 03:30. The glucose response showed the same pattern. The insulin response to food intake in night working nurses is more pronounced in the night compared with morning and evening. The results would have implications for metabolic and cardiovascular disorders in night workers.

Place, publisher, year, edition, pages
2002. Vol. 16, no 2, 133-141 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-3884PubMedID: 12102366OAI: oai:DiVA.org:umu-3884DiVA: diva2:142780
Available from: 2004-04-20 Created: 2004-04-20 Last updated: 2010-08-02Bibliographically approved
In thesis
1. Metabolic disturbances in shift workers
Open this publication in new window or tab >>Metabolic disturbances in shift workers
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

An increased risk for coronary heart disease among shift workers is earlier shown in the epidemiological literature. The aim of this thesis has been to penetrate metabolic disturbances and obesity among shift workers compared to day workers, and to compare if there are differences in total mortality or cause specific mortality of coronary heart disease (CHD), diabetes or ischaemic stroke in between the two groups.

In an intervention study on female nurses (N=11), on night schedules in Umeå hospital, the highest peak value of glucose and insulin after meal ingestion was seen in the late evening (23:30). The post-prandial area under curve (AUC) of glucose and insulin was correspondingly largest after meal ingestion the same clock hour compared to meal ingestion other clock times.

In two different cross-sectional studies Västerbotten Inventory Study (VIP) (N= 27,485) and in a subset of Work, Lipids and Fibrinogen Study (WOLF) (N= 1,324) metabolic differences in between shift and day workers has been evaluated. In both studies have obesity, high triglycerides and low HDL-cholesterol been more prevalent among the shift-working group compared to the day-working group. After adjustments for age and socio-economic factors in the VIP-study obesity and high triglycerides remained as risk factors in shift workers in both men and women. After directly age standardisation, a clustering effect, simultaneously, of two or more metabolic risk factors (obesity, hypertension, and high triglycerides) was seen in both genders among the shift workers compared to the day workers. Correspondingly, in the Wolf study low HDL-cholesterol and high triglycerides remained as significant risk factors after adjustments of confounders as age, socio-economic group, physical activity, current smoking, low social support and high job strain.

In a cohort study from one company (MoDo) with two plants in the pulp and paper industry 2,354 male shift workers and 3,088 male day workers were followed from January 1, 1952 to December 31, 2001 regarding total and cause specific mortality due to CHD, diabetes and ischaemic stroke. Groups of workers defined by different duration of shift exposure were compared with day workers by calculating standardised relative rates (SRR). No increased risk of total mortality was seen among shift workers compared to day workers. Higher duration of shift work was associated with increased risk for CHD, and shift workers with 30 years or more had the highest risk. Diabetes was more common with increasing number of shift year exposure. Compared to day workers shift workers had also an increased risk to die because of ischaemic stroke, with the highest relative difference in the least shift exposed group (< 5 years).

Publisher
55 p.
Series
Umeå University medical dissertations, ISSN 0346-6612
Keyword
shift work, epidemiology, mortality, diabetes, stroke, coronary heart disease, obesity, triglycerides, HDL-cholesterol, insulin, glucose
Research subject
Occupational and Environmental Medicine
Identifiers
urn:nbn:se:umu:diva-242 (URN)91-7305-643-X (ISBN)
Public defence
2004-05-14, Sal B, 9 tr, Tandläkarhögskolan i Umeå, Norrlands Universitetssjukhus, 09:00
Opponent
Available from: 2004-04-20 Created: 2004-04-20 Last updated: 2010-08-02Bibliographically approved

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