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Is there an association between shift work and having a metabolic syndrome?: results from a population based study of 27,485 people
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
2001 (English)In: Occupational and Environmental Medicine, ISSN 1351-0711, E-ISSN 1470-7926, Vol. 58, no 11, 747-752 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES To explore how metabolic risk factors for cardiovascular disease (CVD) differ between shift workers and day workers in a defined population. Shift work has been associated with an increased risk of CVD. Risk factors and causal pathways for this association are only partly known.

METHODS A working population of 27 485 people from the Västerbotten intervention program (VIP) has been analysed. Cross sectional data, including blood sampling and questionnaires were collected in a health survey.

RESULTS Obesity was more prevalent among shift workers in all age strata of women, but only in two out of four age groups in men. Increased triglycerides (>1.7 mmol/l) were more common among two age groups of shift working women but not among men. Low concentrations of high density lipoprotein (HDL) cholesterol (men<0.9 and women<1.0 mmol/l) were present in the youngest age group of shift workers in both men and women. Impaired glucose tolerance was more often found among 60 year old women shift workers. Obesity and high triglycerides persisted as risk factors in shift working men and women after adjusting for age and socioeconomic factors, with an OR of 1.4 for obesity and 1.1 for high triglyceride concentrations. The relative risks for women working shifts versus days with one, two, and three metabolic variables were 1.06, 1.20, and 1.71, respectively. The corresponding relative risks for men were 0.99, 1.30, and 1.63, respectively.

CONCLUSIONS In this study, obesity, high triglycerides, and low concentrations of HDL cholesterol seem to cluster together more often in shift workers than in day workers, which might indicate an association between shift work and the metabolic syndrome.

Place, publisher, year, edition, pages
2001. Vol. 58, no 11, 747-752 p.
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:umu:diva-3885DOI: 10.1136/oem.58.11.747OAI: oai:DiVA.org:umu-3885DiVA: diva2:142781
Available from: 2004-04-20 Created: 2004-04-20 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Metabolic disturbances in shift workers
Open this publication in new window or tab >>Metabolic disturbances in shift workers
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

An increased risk for coronary heart disease among shift workers is earlier shown in the epidemiological literature. The aim of this thesis has been to penetrate metabolic disturbances and obesity among shift workers compared to day workers, and to compare if there are differences in total mortality or cause specific mortality of coronary heart disease (CHD), diabetes or ischaemic stroke in between the two groups.

In an intervention study on female nurses (N=11), on night schedules in Umeå hospital, the highest peak value of glucose and insulin after meal ingestion was seen in the late evening (23:30). The post-prandial area under curve (AUC) of glucose and insulin was correspondingly largest after meal ingestion the same clock hour compared to meal ingestion other clock times.

In two different cross-sectional studies Västerbotten Inventory Study (VIP) (N= 27,485) and in a subset of Work, Lipids and Fibrinogen Study (WOLF) (N= 1,324) metabolic differences in between shift and day workers has been evaluated. In both studies have obesity, high triglycerides and low HDL-cholesterol been more prevalent among the shift-working group compared to the day-working group. After adjustments for age and socio-economic factors in the VIP-study obesity and high triglycerides remained as risk factors in shift workers in both men and women. After directly age standardisation, a clustering effect, simultaneously, of two or more metabolic risk factors (obesity, hypertension, and high triglycerides) was seen in both genders among the shift workers compared to the day workers. Correspondingly, in the Wolf study low HDL-cholesterol and high triglycerides remained as significant risk factors after adjustments of confounders as age, socio-economic group, physical activity, current smoking, low social support and high job strain.

In a cohort study from one company (MoDo) with two plants in the pulp and paper industry 2,354 male shift workers and 3,088 male day workers were followed from January 1, 1952 to December 31, 2001 regarding total and cause specific mortality due to CHD, diabetes and ischaemic stroke. Groups of workers defined by different duration of shift exposure were compared with day workers by calculating standardised relative rates (SRR). No increased risk of total mortality was seen among shift workers compared to day workers. Higher duration of shift work was associated with increased risk for CHD, and shift workers with 30 years or more had the highest risk. Diabetes was more common with increasing number of shift year exposure. Compared to day workers shift workers had also an increased risk to die because of ischaemic stroke, with the highest relative difference in the least shift exposed group (< 5 years).

Publisher
55 p.
Series
Umeå University medical dissertations, ISSN 0346-6612
Keyword
shift work, epidemiology, mortality, diabetes, stroke, coronary heart disease, obesity, triglycerides, HDL-cholesterol, insulin, glucose
Research subject
Occupational and Environmental Medicine
Identifiers
urn:nbn:se:umu:diva-242 (URN)91-7305-643-X (ISBN)
Public defence
2004-05-14, Sal B, 9 tr, Tandläkarhögskolan i Umeå, Norrlands Universitetssjukhus, 09:00
Opponent
Available from: 2004-04-20 Created: 2004-04-20 Last updated: 2010-08-02Bibliographically approved

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