umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Metabolic disturbances in male workers with rotating three-shift work: results of the WOLF study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
2003 (English)In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 76, no 6, 424-430 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: The aim of the present study was to investigate the relationship between important metabolic risk factors for coronary heart disease (CHD) and type 2 diabetes in shift workers and day workers.

Methods: Cross-sectional data from a sub-population in the WOLF study consisting of 665 day workers and 659 three-shift workers in two plants were analysed.

Results: A higher proportion of shift workers than day workers had high triglyceride levels (‡1.7 mmol/l), low levels of HDL-cholesterol (<0.9 mmol/l) and abdominal obesity (waist/hip ratio>0.9). The risk of low HDLcholesterol was doubled in shift workers, (odds ratio (OR): 2.02, 95% confidence interval (95% CI): 1.24– 3.28) after being adjusted for age, socio-economic factors, physical activity, current smoking, social support and job strain. High levels of triglycerides were also significantly associated with shift work (OR: 1.40, 95% CI: 1.08–1.83). The OR for abdominal obesity was 1.19, (95% CI: 0.92–1.56). The prevalence of hyperglycaemia (serum glucose ‡7.0 mmol/l) was similar in day and shift workers. No significant interaction was seen between shift work and abdominal obesity with regard to the associations with triglycerides and HDL-cholesterol.

Conclusions: We found a significant association between shift work and lipid disturbances (i.e. low HDL-cholesterol and high triglyceride levels). We did not find any association with hyperglycaemia.

Place, publisher, year, edition, pages
2003. Vol. 76, no 6, 424-430 p.
Keyword [en]
shift work, metabolic factors, abdominal, obesity, job strain
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:umu:diva-3886DOI: 10.1007/s00420-003-0440-yOAI: oai:DiVA.org:umu-3886DiVA: diva2:142782
Available from: 2004-04-20 Created: 2004-04-20 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Metabolic disturbances in shift workers
Open this publication in new window or tab >>Metabolic disturbances in shift workers
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

An increased risk for coronary heart disease among shift workers is earlier shown in the epidemiological literature. The aim of this thesis has been to penetrate metabolic disturbances and obesity among shift workers compared to day workers, and to compare if there are differences in total mortality or cause specific mortality of coronary heart disease (CHD), diabetes or ischaemic stroke in between the two groups.

In an intervention study on female nurses (N=11), on night schedules in Umeå hospital, the highest peak value of glucose and insulin after meal ingestion was seen in the late evening (23:30). The post-prandial area under curve (AUC) of glucose and insulin was correspondingly largest after meal ingestion the same clock hour compared to meal ingestion other clock times.

In two different cross-sectional studies Västerbotten Inventory Study (VIP) (N= 27,485) and in a subset of Work, Lipids and Fibrinogen Study (WOLF) (N= 1,324) metabolic differences in between shift and day workers has been evaluated. In both studies have obesity, high triglycerides and low HDL-cholesterol been more prevalent among the shift-working group compared to the day-working group. After adjustments for age and socio-economic factors in the VIP-study obesity and high triglycerides remained as risk factors in shift workers in both men and women. After directly age standardisation, a clustering effect, simultaneously, of two or more metabolic risk factors (obesity, hypertension, and high triglycerides) was seen in both genders among the shift workers compared to the day workers. Correspondingly, in the Wolf study low HDL-cholesterol and high triglycerides remained as significant risk factors after adjustments of confounders as age, socio-economic group, physical activity, current smoking, low social support and high job strain.

In a cohort study from one company (MoDo) with two plants in the pulp and paper industry 2,354 male shift workers and 3,088 male day workers were followed from January 1, 1952 to December 31, 2001 regarding total and cause specific mortality due to CHD, diabetes and ischaemic stroke. Groups of workers defined by different duration of shift exposure were compared with day workers by calculating standardised relative rates (SRR). No increased risk of total mortality was seen among shift workers compared to day workers. Higher duration of shift work was associated with increased risk for CHD, and shift workers with 30 years or more had the highest risk. Diabetes was more common with increasing number of shift year exposure. Compared to day workers shift workers had also an increased risk to die because of ischaemic stroke, with the highest relative difference in the least shift exposed group (< 5 years).

Publisher
55 p.
Series
Umeå University medical dissertations, ISSN 0346-6612
Keyword
shift work, epidemiology, mortality, diabetes, stroke, coronary heart disease, obesity, triglycerides, HDL-cholesterol, insulin, glucose
Research subject
Occupational and Environmental Medicine
Identifiers
urn:nbn:se:umu:diva-242 (URN)91-7305-643-X (ISBN)
Public defence
2004-05-14, Sal B, 9 tr, Tandläkarhögskolan i Umeå, Norrlands Universitetssjukhus, 09:00
Opponent
Available from: 2004-04-20 Created: 2004-04-20 Last updated: 2010-08-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Karlsson, Berndt HKnutsson, Anders KLindahl, Bernt O
By organisation
Occupational MedicineDepartment of Public Health and Clinical Medicine
In the same journal
International Archives of Occupational and Environmental Health
Environmental Health and Occupational Health

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 386 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf