Diurnal effects of enriched environment in immediate early gene expression in the rat brain
2005 (English)In: Brain research, ISSN 0006-8993, Vol. 1046, no 1-2, 137-144 p.Article in journal (Refereed) Published
Rodents housed in an enriched environment (EE) show increased neuronal plasticity with enhanced long-term potentiation and memory performance. We report an EE-induced increase in NGFI-A and Krox-20 mRNA expression exclusively during the dark period of the day. In addition, EE-housed rats showed considerable diurnal variation in NGFI-A, Krox-20, and NGFI-B mRNA expression which was absent in single-housed rats. Thus, EE-induced molecular changes are more evident during the dark phase when the rats have higher motor and exploratory activity. This is important to take into account in future studies of molecular mediators of experience-dependent neuronal plasticity.
Place, publisher, year, edition, pages
2005. Vol. 1046, no 1-2, 137-144 p.
analysis of variance, animals, brain/metabolism, circadian rhythm/genetics/*physiology, DNA-binding proteins/genetics/*metabolism, darkness, early growth response protein 1, early growth response protein 2, environment, gene expression/physiology, immediate-early proteins/genetics/*metabolism, male, neuronal plasticity/physiology, RNA, messenger/analysis, rats, sprague-dawley, Receptors, cytoplasmic and nuclear/genetics/metabolism, receptors, steroid/genetics/metabolism, transcription factors/genetics/*metabolism
IdentifiersURN: urn:nbn:se:umu:diva-3999DOI: doi:10.1016/j.brainres.2005.03.051PubMedID: 15927552OAI: oai:DiVA.org:umu-3999DiVA: diva2:142930