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Genetic epidemiology of prostate cancer
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Prostate cancer is a major health burden throughout the world, yet the etiology of prostate cancer is poorly understood. Evidence has accumulated supporting the existence of a hereditary form of this disease. Improved understanding of the genetic mechanisms underlying the development and progression of prostate cancer would be a major advance for improved prevention, detection and treatment strategies. This thesis evaluates different aspects of the genetic epidemiology of prostate cancer.

In a genomic scan two chromosomal regions with evidence for linkage was observed. The strongest support was found on chromosome 19p with an allele sharing LOD score of 2.91 (genome-wide P = 0.032). The second region, showing suggestive evidence of linkage, was observed in the centromeric region of chromosome 5. Linkage analyses of densely spaced markers on chromosome 8p22-23 confirmed (P = 0.03) previously reported linkage to this region. A systematic evaluation of the possible impact that the RNASEL gene have on prostate cancer was performed. Overall, limited evidence for association with prostate cancer risk was found. The results provide strong evidence against a role of RNASEL in prostate cancer etiology in Sweden. In a comprehensive evaluation of occurrence of other malignancies in HPC families, previously reported association between gastric and prostate carcinoma was confirmed. The increased risk was of the same magnitude in early and late onset HPC families and confined to only male relatives. A genome-wide linkage analysis, stratified by occurrence of gastric carcinoma, identified a novel susceptibility locus on chromosome Xp21.

In summary, chromosome 5q and 19p represents the regions most likely to harbor susceptibility genes predisposing to prostate cancer in the Swedish population. A common genetic basis for both gastric and prostate cancer has been confirmed and a novel susceptibility locus on chromosome Xp21 has been identified.

Place, publisher, year, edition, pages
Umeå: Umeå university , 2004. , 46 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 900
Keyword [en]
Oncology, prostate cancer, epidemiology, genetics, linkage analysis, genome-wide scan
Keyword [sv]
Onkologi
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:umu:diva-281ISBN: 91-7305-669-3 (print)OAI: oai:DiVA.org:umu-281DiVA: diva2:142949
Public defence
2004-06-04, Lionsalen (244), By 7, Norrlands Universitetssjukhus, Umeå, 13:00
Opponent
Supervisors
Available from: 2004-05-13 Created: 2004-05-13 Last updated: 2010-08-27Bibliographically approved
List of papers
1. Genome-wide scan of Swedish families with hereditary prostate cancer: suggestive evidence of linkage at 5q11.2 and 19p13.3
Open this publication in new window or tab >>Genome-wide scan of Swedish families with hereditary prostate cancer: suggestive evidence of linkage at 5q11.2 and 19p13.3
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2003 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 57, no 4, 290-297 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-4010 (URN)10.1002/pros.10303 (DOI)
Available from: 2004-05-13 Created: 2004-05-13 Last updated: 2017-12-14Bibliographically approved
2. Linkage analysis of prostate cancer susceptibility: confirmation of linkage at 8p22-23
Open this publication in new window or tab >>Linkage analysis of prostate cancer susceptibility: confirmation of linkage at 8p22-23
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2003 (English)In: Human Genetics, ISSN 0340-6717, E-ISSN 1432-1203, Vol. 112, no 4, 414-418 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-4011 (URN)10.1007/s00439-003-0916-6 (DOI)
Available from: 2004-05-13 Created: 2004-05-13 Last updated: 2017-12-14Bibliographically approved
3. Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer
Open this publication in new window or tab >>Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer
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2004 (English)In: Clinical Cancer Research, ISSN 1078-0432, E-ISSN 1557-3265, Vol. 10, no 21, 7150-7156 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-15603 (URN)15534086 (PubMedID)
Available from: 2006-11-13 Created: 2006-11-13 Last updated: 2017-12-14Bibliographically approved
4. Comprehensive evaluation of malignancies associated with hereditary prostate cancer: confirmation of a common genetic basis for prostate and gastric cancer and suggestive linkage to Xp21
Open this publication in new window or tab >>Comprehensive evaluation of malignancies associated with hereditary prostate cancer: confirmation of a common genetic basis for prostate and gastric cancer and suggestive linkage to Xp21
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(English)Manuscript (preprint) (Other academic)
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-4013 (URN)
Available from: 2004-05-13 Created: 2004-05-13 Last updated: 2017-01-30Bibliographically approved

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CiteExportLink to record
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Citation style
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