Elevated neurofilament levels in neurological diseases
2003 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 987, no 1, 25-31 p.Article in journal (Refereed) Published
Neurofilaments, a major cytoskeletal constituent of neuronal cells, can be released into the cerebrospinal fluid during several neurodegenerative diseases. By means of a new sensitive ELISA capable of measuring 60 ng/l of neurofilament light, significant elevations were observed for different neurological disorders. Cerebral infarction presented levels of 19800+/-9100 ng/l, amyothropic lateral sclerosis 3600+/-1200 ng/l, 'relapsing-remitting' MS 2500+/-1500 ng/l, extrapyramidal symptoms 1100+/-300 ng/l, late onset AD 300+/-100 ng/l and vascular dementia 1400+/-800 ng/l. In patients with no signs of neurological diseases the upper normal level and cut-off values was determined to be below 100 ng/l. NF-L determinations will be a valuable complement in identifying neuronal degradation and can be used clinically for diagnostic and monitoring purposes.
Place, publisher, year, edition, pages
2003. Vol. 987, no 1, 25-31 p.
Neurofilament protein, ELISA, Cerebrospinal fluid, Neurodegenerative disease
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-4217DOI: 10.1016/S0006-8993(03)03219-0PubMedID: 14499942OAI: oai:DiVA.org:umu-4217DiVA: diva2:143220