Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?
2002 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 41, no 4, 352-354 p.Article in journal (Refereed) Published
The LRIG1 gene (formerly LIG-1), recently cloned by us, displays structural similarities to the Drosophila Kek I gene. Kek I encodes a cell surface protein, Kekkon-1, which inhibits epidermal growth factor receptor-mediated signalling. We localized the LRIG1 gene to chromosome band 3p14.3, a region known to be deleted in various human cancers. In the present study LRIG1 gene expression was examined in different tumour cell lines and corresponding normal tissues by real-time RT-PCR. In many tumour cell lines, LRIG1 expression appeared absent or was down regulated compared to corresponding normal tissues. The results are consistent with LRIG1 being a tumour suppressor gene in humans. However, further studies are justified to elucidate the explicit role of LRIG1 as a negative regulator of oncogenesis.
Place, publisher, year, edition, pages
2002. Vol. 41, no 4, 352-354 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-4262DOI: 10.1080/028418602760169398PubMedID: 12234026OAI: oai:DiVA.org:umu-4262DiVA: diva2:143278