A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster
2003 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 4, no 8, 781-786 p.Article in journal (Refereed) Published
The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, which encodes a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans, the t(2;5) translocation, which involves the ALK locus, produces an active form of ALK, which is the causative agent in non-Hodgkin's lymphoma. The physiological function of the Alk RTK, however, is unknown. In this paper, we describe loss-of-function mutants in the Drosophila Alk gene that cause a complete failure of the development of the gut. We propose that the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development.
Place, publisher, year, edition, pages
Nature Publishing Group , 2003. Vol. 4, no 8, 781-786 p.
IdentifiersURN: urn:nbn:se:umu:diva-4345DOI: 10.1038/sj.embor.embor897OAI: oai:DiVA.org:umu-4345DiVA: diva2:143392