Dopamine D2 receptor gene Ser311Cys variant and schizophrenia: Association study and meta-analysis
2003 (English)In: American Journal of Medical Genetics, ISSN 0148-7299, Vol. 119B, no 1, 28-34 p.Article in journal (Refereed) Published
An association has been reported between a dopamine D(2) receptor gene (DRD2) Ser311Cys variant and schizophrenia. In a replication attempt, Swedish patients with schizophrenia (n = 173) and control subjects (n = 236) were assessed for the DRD2 Ser311Cys variant. Schizophrenic patients displayed higher Cys311 allele frequencies than control subjects (4.0 vs. 0.8%, chi(2) = 9.49, df = 1, P = 0.002; odds ratio (OR) 4.93, 95% confidence interval (95% CI) 1.61-15.12). The association was detected only in men. The results were supported by a meta-analysis of all published case-control studies comprising a total of 9,152 subjects (chi(2) = 11.37, df = 1, P < 0.001; OR 1.43, 95% CI 1.16-1.78). The present results support the involvement of the DRD2 gene in the pathogenesis of schizophrenia. Copyright 2003 Wiley-Liss, Inc.
Place, publisher, year, edition, pages
2003. Vol. 119B, no 1, 28-34 p.
genetics, dopamine D2 receptor gene locus (DRD2), dopamine receptors
IdentifiersURN: urn:nbn:se:umu:diva-4832DOI: 10.1002/ajmg.b.20004PubMedID: 12707934OAI: oai:DiVA.org:umu-4832DiVA: diva2:144082