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Applanation resonance tonometry for intraocular pressure in humans
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).ORCID-id: 0000-0003-2055-576X
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Oftalmiatrik.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
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2004 (Engelska)Ingår i: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 25, nr 4, s. 1053-1065Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Glaucoma is a group of diseases associated with optic nerve damage and loss of visual field. The aetiology is not completely understood, but one of the major risk factors is elevated intraocular pressure (IOP). Reliable methods for measuring the IOP are therefore important. The aim of the study was to investigate the ability of the applanation resonance tonometry (ART) system, based on continuous force and area recording, to measure IOP in humans. Both the phase of initial indentation (IOPIndentation) and the phase when the sensor was removed (IOPRemoval) from the cornea were analysed. The Goldmann applanation tonometry (GAT) was used as reference method. The study included 24 healthy volunteers with normal IOP and 24 patients with elevated IOP. The correlation and standard deviation (SD) between IOPIndentation and IOPGAT was R = 0.92 (p < 0.001), SD = 3.6 mmHg, n = 104, and between IOPRemoval and IOPGAT R = 0.94 (p < 0.001), SD = 3.1 mmHg, n = 104. In conclusion, resonance sensor technology has made it possible to introduce a new multi-point method for measuring IOP, and the method is relevant for measuring IOP in humans. The study indicates that with further development towards elimination of position dependence, the ART has the potential to become a useful clinical instrument for IOP measurement.

Ort, förlag, år, upplaga, sidor
2004. Vol. 25, nr 4, s. 1053-1065
Nyckelord [en]
applanation resonance tonometry, glaucom, IOP
Nationell ämneskategori
Medicin och hälsovetenskap Oftalmologi
Forskningsämne
oftalmiatrik
Identifikatorer
URN: urn:nbn:se:umu:diva-5126DOI: 10.1088/0967-3334/25/4/021PubMedID: 15382841Lokalt ID: 744OAI: oai:DiVA.org:umu-5126DiVA, id: diva2:144518
Tillgänglig från: 2006-05-03 Skapad: 2006-05-03 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Ingår i avhandling
1. Applanation Resonance Tonometry for Intraocular Pressure Measurement
Öppna denna publikation i ny flik eller fönster >>Applanation Resonance Tonometry for Intraocular Pressure Measurement
2006 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma. Since glaucoma is a leading cause of blindness, reliable methods for measuring the IOP are important. This doctoral dissertation presents a new method, applanation resonance tonometry (ART), for measurement of IOP. The method is based on resonance sensor technology combined with the novel multipoint analysis of continuously sampled data of both contact force and contact area. The ART was evaluated in in vitro porcine-eye studies as well as in clinic on both healthy volunteers and patients.

A new symmetric probe with a larger sensor tip and improved aligning light was developed and evaluated in vitro. It showed that the error from off-centring was highly reduced. The new ART probe, used as a biomicroscope device (ARTBiom) and as a handheld device (ARTHand), was further evaluated in a clinical study designed in accordance with the International Standard Organisation’s (ISO) requirement. Both the ARTBiom and the ARTHand met the precision set by the requirements.

Laser surgery is a common way to correct vision. The biomechanical effect of photorefractive keratectomy (PRK) on IOP measurements was evaluated using Goldmann applanation tonometry (GAT) and ART in an in vitro study. Both methods were affected, but to a different extent. The flat contact probe of GAT, as compared with the convex tip of ART, and single point vs. multipoint approach, provide explanation to the ART advantage regarding measurement error of IOP after PRK.

In conclusion, resonance sensor technology has made it possible to introduce a new multipoint method for measuring IOP, and the method is relevant for measuring IOP in humans. It may be possible to reduce errors in the clinical measurement of IOP with this new method, especially after corneal surgery. The ART has the potential to become a useful clinical instrument for IOP measurement.

Ort, förlag, år, upplaga, sidor
Umeå: Tillämpad fysik och elektronik, 2006. s. 63
Serie
Resonance Sensor Lab, ISSN 1653-6789 ; 1
Nyckelord
Physics, Resonance, applanation, tonometry, glaucoma, Goldmann, biomechanical, Intraocular, ART, Fysik
Forskningsämne
fysik
Identifikatorer
urn:nbn:se:umu:diva-784 (URN)91-7264-061-8 (ISBN)
Disputation
2006-05-24, Sal B, 9tr., Tandläkarhögskolan, Norrlands Universitetssjukhus, Umeå, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2006-05-03 Skapad: 2006-05-03 Senast uppdaterad: 2010-02-01Bibliografiskt granskad

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Hallberg, PerLindén, ChristinaLindahl, Olof A.Bäcklund, TomasEklund, Anders

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Centrum för medicinsk teknik och fysik (CMTF)OftalmiatrikInstitutionen för tillämpad fysik och elektronik
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