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APOE influences on neurosychological function after mild head injury: within-person comparisons
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Social Sciences, Department of Psychology.
Department of Psychology, Stockholm University.
Depatrment of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium.
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2004 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 62, no 11, 1963-1966 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To examine the relationship between neuropsychological outcome following mild head injury (MHI) and APOE genotype.

Methods: Data from a population-based longitudinal study (n = 3,500) were used to identify 34 adults who experienced MHI during the course of the study. Their pre- and postinjury performances on a battery of nine neuropsychological tests were compared within person, and the postinjury performance was compared with that of age- and gender-matched control subjects.

Results: The within-person comparisons showed that participants with at least oneAPOE ε4 allele (n = 11) had a significantly decreased postinjury performance on three of the tests, whereas the postinjury performance for APOE ε4-negative participants (n = 23) was unchanged. There was no significant difference in postinjury performance between participants with/without the ε4 allele, and neither group was impaired relative to controls.

Conclusions: APOE genotype may influence the outcome following an MHI. Pre/postinjury within-person comparisons seem more sensitive than control group comparisons for detecting injury-related effects.

Place, publisher, year, edition, pages
Minneapolis, Minn: Lancet Publications Inc. , 2004. Vol. 62, no 11, 1963-1966 p.
URN: urn:nbn:se:umu:diva-5270DOI: 10.1212/01.WNL.0000129268.83927.A8OAI: diva2:144735
Available from: 2006-09-04 Created: 2006-09-04 Last updated: 2011-04-13Bibliographically approved
In thesis
1. Mild head injury: Relation to cognition, dementia, fatigue & genetics
Open this publication in new window or tab >>Mild head injury: Relation to cognition, dementia, fatigue & genetics
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Following a mild head injury (MHI), a person may report a variety of symptoms such as headache, memory disturbance, dizziness, and concentration difficulties. For most persons the symptoms are transient, but some suffer persistent symptoms that can have a major impact on everyday life. It remains poorly understood why some but not others have full recovery after MHI. The aim of this thesis was to investigate outcomes after MHI, with particular focus on neuropsychological functioning, fatigue, and risk of dementia. A related objective was to examine the potential association of a genetic factor, Apolipoprotein (APOE), with MHI outcome. The APOE є4 allele has been associated with unfavorable outcomes after moderate or severe head injury, but little is known about its influence on outcome after MHI. In Study I and II, data from a population-based longitudinal study were used to compare neuropsychological functioning and fatigue before and after MHI. The results from Study I showed a post-injury decline in neuropsychological performance for є4-carriers, whereas the performance remained unchanged for non-carriers. Study II showed an increase in self-reported fatigue after MHI for both є4-carriers and non-carriers, with a more pronounced increase for є4-carriers. In Study III, a case-control study was conducted to examine whether a history of MHI increased the risk of developing dementia later in life. It was found that MHI alone did not increase the risk, but the combination of MHI and APOE є4 was associated with increased risk of dementia. Taken together, the studies generally indicate a positive outcome after MHI, but in combination with APOE є4 even mild head injury may lead to long-lasting negative outcomes. Consideration of pre-injury level of functioning and genetic factors seems critical for a complete understanding of the impact of MHI.

Place, publisher, year, edition, pages
Umeå: Psykologi, 2006
Neuropsychology, mild head injury, mild brain injury, apolipoprotein E
National Category
urn:nbn:se:umu:diva-852 (URN)91-7264-158-4 (ISBN)
Public defence
2006-09-15, Beteendevetarhuset, Bt 102, Umeå universitet, Umeå, 10:15 (English)
Available from: 2006-09-04 Created: 2006-09-04 Last updated: 2011-04-15Bibliographically approved

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Sundström, AnnaMarklund, PetterNilsson, Lars-GöranAdolfsson, RolfNyberg, Lars
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