APOE influences on neurosychological function after mild head injury: within-person comparisons
2004 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 62, no 11, 1963-1966 p.Article in journal (Refereed) Published
Objective: To examine the relationship between neuropsychological outcome following mild head injury (MHI) and APOE genotype.
Methods: Data from a population-based longitudinal study (n = 3,500) were used to identify 34 adults who experienced MHI during the course of the study. Their pre- and postinjury performances on a battery of nine neuropsychological tests were compared within person, and the postinjury performance was compared with that of age- and gender-matched control subjects.
Results: The within-person comparisons showed that participants with at least oneAPOE ε4 allele (n = 11) had a significantly decreased postinjury performance on three of the tests, whereas the postinjury performance for APOE ε4-negative participants (n = 23) was unchanged. There was no significant difference in postinjury performance between participants with/without the ε4 allele, and neither group was impaired relative to controls.
Conclusions: APOE genotype may influence the outcome following an MHI. Pre/postinjury within-person comparisons seem more sensitive than control group comparisons for detecting injury-related effects.
Place, publisher, year, edition, pages
Minneapolis, Minn: Lancet Publications Inc. , 2004. Vol. 62, no 11, 1963-1966 p.
IdentifiersURN: urn:nbn:se:umu:diva-5270DOI: 10.1212/01.WNL.0000129268.83927.A8OAI: oai:DiVA.org:umu-5270DiVA: diva2:144735