Mutagenic Hazards of Complex Polycyclic Aromatic Hydrocarbon Mixtures in Contaminated Soil.
2008 (English)In: Environmental Toxicology and Chemistry, ISSN 0730-7268, Vol. 27, no 4, 978-90 p.Article in journal (Refereed) Published
The objective of this study was to evaluate hazard/risk assessment methods for complex environmental mixtures that involve a targeted, priority chemical approach based on the cumulative hazard/risk of known mixture components or analyses of sufficiently similar mixtures. Ten polycyclic aromatic hydrocarbon (PAH)-contaminated soils were separated into non-polar and semi-polar fractions, and both fractions elicited positive responses on the Salmonella reverse mutation assay. Targeted and non-targeted methods of hazard prediction routinely provided overestimations of observed mutagenic activities for the non-polar soil fractions, suggesting non-additive interactions of PAHs in complex mixtures. This suggests that current risk assessment methods for complex mixtures may provide conservative estimates for soils contaminated with priority PAHs alone. However, significant underestimations of total risk will be obtained if the soils also contain unidentified PAHs, as well as polycyclic aromatic compounds (PACs) and related compounds that contribute to the total mutagenic activity. Furthermore, estimates of excess lifetime cancer risk associated with the non-dietary ingestion of the PAH-contaminated soils studied here indicate that a traditional risk assessment model based on identified priority PAHs and an assumption of additivity, generally provides an underestimate of the risk associated with the non-polar soil fractions (in comparison with bioassay-derived risk estimates). Additional cancer risk may be associated with the more polar compounds that are also found at these contaminated sites, and that are rarely included in the standard risk assessment methodology.
Place, publisher, year, edition, pages
2008. Vol. 27, no 4, 978-90 p.
IdentifiersURN: urn:nbn:se:umu:diva-5778DOI: doi:10.1897/07-157PubMedID: 18027996OAI: oai:DiVA.org:umu-5778DiVA: diva2:145446