Retinoic acid signalling specifies intermediate character in the developing telencephalon.
2004 (English)In: Development, ISSN 0950-1991, Vol. 131, no 17, 4323-4332 p.Article in journal (Refereed) Published
The organisation of the telencephalon into its major structures depends on its early regionalisation along the dorsoventral axis. Previous studies have provided evidence that sonic hedgehog (SHH) is required for the generation of telencephalic cells of ventral character, and that sequential WNT and fibroblast growth factor (FGF) signalling specifies cells of dorsal telencephalic character. However, the signalling mechanisms that specify telencephalic cells of an intermediate character remain to be defined. We provide evidence here that retinoic acid has a crucial role in specifying telencephalic progenitor cells of intermediate character.
Place, publisher, year, edition, pages
2004. Vol. 131, no 17, 4323-4332 p.
Animals, Cell Division, Chick Embryo, Cloning; Molecular, DNA; Complementary/metabolism, Fibroblast Growth Factors/metabolism, Homeodomain Proteins/genetics/metabolism, Immunohistochemistry, In Situ Hybridization, Mice, Models; Biological, Organ Culture Techniques, Protein Structure; Tertiary, Signal Transduction, Telencephalon/*embryology/metabolism, Time Factors, Trans-Activation (Genetics), Transcription Factors, Tretinoin/*metabolism
IdentifiersURN: urn:nbn:se:umu:diva-5816DOI: 10.1242/dev.01308PubMedID: 15294870OAI: oai:DiVA.org:umu-5816DiVA: diva2:145484