Change search
ReferencesLink to record
Permanent link

Direct link
Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments.
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
2005 (English)In: Developmental Dynamics, ISSN 1058-8388, Vol. 232, no 4, 1105-1114 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 232, no 4, 1105-1114 p.
Keyword [en]
Animals, Female, Gene Expression Regulation; Developmental/*physiology, Islets of Langerhans/cytology/*embryology, Male, Metalloendopeptidases/*biosynthesis, Mice, Mice; Inbred CBA, Organ Specificity/physiology
URN: urn:nbn:se:umu:diva-5826DOI: 10.1002/dvdy.20259PubMedID: 15739225OAI: diva2:145494
Available from: 2007-11-30 Created: 2007-11-30Bibliographically approved
In thesis
1. Spleno-pancreatic development assessed by 3D molecular imaging
Open this publication in new window or tab >>Spleno-pancreatic development assessed by 3D molecular imaging
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The development of different organs and tissues along the gastrointestinal tract, including the pancreas, depends on signalling between the endoderm and the adjacent mesenchyme. The Nkx gene Bapx1 is involved in spatial control of organ-positioning in the spleno-pancreatic region, and deficiency in this gene results in unacceptable proximity of the splenic mesenchyme to the pancreas. This permits agitating signals from the splenic mesenchyme to induce an in vivo (and in vitro) transformation of pancreatic epithelium to a cystic structure with gut like features. Also, wild type splenic mesenchyme is competent to induce a similar transformation. These findings illustrate the importance for strict control of organ positioning during spleno-pancreatic development.

Several growth factors and receptors involved in pancreatic development are activated by protease processing. Some of these growth factors have been implicated as substrates for members of the A Disintegrin And Metalloprotease (ADAM) family. The ADAMs 9, 10, and 17 are expressed during pancreatic development and in the adult pancreas, suggesting a possible role for these ADAMs in pancreatic development and function.

Animal model systems are widely used to investigate gene function during development and disease. However, spatial, molecular, and quantitative phenotype screening in animals is a time consuming effort. Optical Projection Tomography is a 3-dimensional imaging technique that, in combination with improvements in sample preparation and computer processing, can be used to visualize and quantify characteristics of intact adult mouse organs such as the total β-cell content in the pancreas.

Place, publisher, year, edition, pages
Umeå: Umeå centrum för molekylär medicin (UCMM), 2007. 94 p.
Umeå University medical dissertations, ISSN 0346-6612 ; 1064
Cell biology, Spleen, Pancreas, Imaging, Development, Cellbiologi
Research subject
Developmental Biology
urn:nbn:se:umu:diva-987 (URN)91-7264-203-3 (ISBN)
Public defence
2007-02-15, Betula, Byggnad 6M, Umeå, 09:00 (English)
Available from: 2007-01-31 Created: 2007-01-31 Last updated: 2009-05-14Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Alanentalo, TomasAhlgren, Ulf
By organisation
Umeå Centre for Molecular Medicine (UCMM)
In the same journal
Developmental Dynamics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 38 hits
ReferencesLink to record
Permanent link

Direct link