Specification of dorsal telencephalic character by sequential Wnt and FGF signaling.
2003 (English)In: Nature Neuroscience, ISSN 1097-6256, Vol. 6, no 7, 701-707 p.Article in journal (Refereed) Published
Dorsoventral patterning of the telencephalon is established early in forebrain development and underlies many of the regional subdivisions that are critical to the later organization of neural circuits in the cerebral cortex and basal ganglia. Sonic hedgehog (Shh) is involved in the generation of the ventral-most telencephalic cells, but the identity of the extrinsic signal(s) that induce dorsal character in telencephalic cells is not known. Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character.
Place, publisher, year, edition, pages
2003. Vol. 6, no 7, 701-707 p.
Aging/genetics/metabolism, Animals, Basic Helix-Loop-Helix Transcription Factors, Bone Morphogenetic Proteins/physiology, Cell Differentiation, Chick Embryo, Ectoderm/cytology/physiology, Embryonic Induction/*physiology, Epithelium, Eye Proteins, Fibroblast Growth Factors/classification/genetics/*physiology, Frizzled Receptors, Gene Expression Regulation; Developmental, Homeodomain Proteins/genetics/metabolism, Immunohistochemistry, In Situ Hybridization/methods, Mice, Nerve Tissue Proteins/genetics/metabolism, Organ Culture Techniques, Paired Box Transcription Factors, Proteins/physiology, Proto-Oncogene Proteins/genetics/*physiology, Pyrroles/pharmacology, Receptors; Fibroblast Growth Factor/physiology, Repressor Proteins, Signal Transduction/genetics/*physiology, Stem Cells/metabolism, Telencephalon/cytology/embryology/metabolism/*physiology, Transcription Factors, Wnt Proteins, Zebrafish Proteins
IdentifiersURN: urn:nbn:se:umu:diva-5932DOI: 10.1038/nn1068PubMedID: 12766771OAI: oai:DiVA.org:umu-5932DiVA: diva2:145600