Regional cyclin D1 overexpression or hypoxia correlate inversely with heterogeneous oestrogen receptor-alpha expression in human breast cancer.
2003 (English)In: In Vivo, ISSN 0258-851X, Vol. 17, no 4, 311-8 p.Article in journal (Refereed) Published
Substance P (SP) has been implicated in the pathophysiology of ulcerative colitis (UC) and it has been suggested that blocking of its effect would be advantageous in this disease. Eosinophils have also been implicated in the pathophysiology of UC. In the present study, specimens from the sigmoid colon of UC patients were investigated by the use of antisera against SP and the neurokinin-1 receptor (NK-1R) and staining for demonstration of eosinophils. The degrees of SP innervation and NK-1R immunoreaction, as well as the levels of eosinophil infiltration, varied between different patients. Interestingly, NK-1R immunoreaction in the epithelium was often seen to be the most marked where there were numerous eosinophils in the underlying mucosa and where the mucosa showed a marked morphologic derangement. The observations suggest that there are marked fluctuations in effects of SP and eosinophils during the disease. The infiltrating eosinophils may be involved in the destruction of the mucosal tissue. Furthermore, for the majority of cases where there is marked derangement of the mucosa, it is apparent that there is an upregulation of the NK-1 receptor in the epithelium in parallel with the infiltration of the eosinophils.
Place, publisher, year, edition, pages
2003. Vol. 17, no 4, 311-8 p.
Aged, Blotting; Western, Breast Neoplasms/genetics/*metabolism/pathology, Carcinoma/genetics/*metabolism/secondary, Cell Hypoxia, Cell Line; Tumor, Cyclin D1/genetics/*metabolism, Down-Regulation, Estrogen Receptor alpha, Female, Gene Amplification, Gene Expression Regulation; Neoplastic, Humans, Hypoxia-Inducible Factor 1; alpha Subunit, Immunohistochemistry, In Situ Hybridization; Fluorescence, Middle Aged, Neoplasm Staging, Receptors; Estrogen/genetics/*metabolism, Transcription Factors/genetics/metabolism, Tumor Markers; Biological/metabolism
IdentifiersURN: urn:nbn:se:umu:diva-6008PubMedID: 12929585OAI: oai:DiVA.org:umu-6008DiVA: diva2:145676