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Platelet serotonin 5-HT2A receptor binding in patients with carcinoid tumor
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Pharmacology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Pharmacology.
2004 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 64, no 1, 3-8 p.Article in journal (Refereed) Published
Abstract [en]

Background: As carcinoid tumors produce and secrete serotonin, various serotonin markers in blood, plasma and urine have been used as diagnostic tools, and quantification of the urinary excretion of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) is the method most frequently used.

Methods: [ 3 H]lysergic acid diethylamide ([ 3 H]LSD) binding to the platelet serotonin 5-HT 2A receptor was investigated in nine patients with carcinoid tumors. The possible effect of serotonin-rich food on the receptor binding was also investigated.

Results: B max for [ 3 H]LSD binding was significantly lower in the carcinoid group than in the control group (mean±SD: 17.6±1.3 vs. 23.9±5.2 fmol/mg protein; p=0.007). K d for [ 3 H]LSD binding was significantly higher in the carcinoid group than in the control group (median: 1.14 vs. 0.71 nmol/L; p=0.03). B max was inversely related to the urinary 5-HIAA excretion, but the correlation did not reach statistical significance (r s =-0.57; p=0.14). Intake of five bananas per day for one week had no effect on B max or K d in healthy volunteers.

Conclusions: The results are consistent with a down-regulation of the 5-HT 2A receptor as a response to the high serotonin levels found in patients with carcinoid tumors. Intake of serotonin-rich food does not affect the receptor characteristics. Further studies are needed to determine whether the platelet 5-HT 2A receptor status can be used as a supplement to urinary 5-HIAA and other biochemical variables in carcinoid tumors.

Place, publisher, year, edition, pages
Oslo: Taylor & Francis , 2004. Vol. 64, no 1, 3-8 p.
Keyword [en]
Aged, Blood Platelets/drug effects/*metabolism, Carcinoid Tumor/*diagnosis/metabolism, Down-Regulation, Female, Humans, Hydroxyindoleacetic Acid/metabolism/urine, Lysergic Acid Diethylamide/metabolism/pharmacology, Male, Middle Aged, Musa/chemistry, Receptor; Serotonin; 5-HT2A/blood/*metabolism, Serotonin/*metabolism, Tumor Markers; Biological/urine
Identifiers
URN: urn:nbn:se:umu:diva-6044PubMedID: 15025423OAI: oai:DiVA.org:umu-6044DiVA: diva2:145712
Available from: 2007-12-05 Created: 2007-12-05 Last updated: 2017-12-14Bibliographically approved

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