Change search
ReferencesLink to record
Permanent link

Direct link
Effects of fucosylated milk of goat and mouse on Helicobacter pylori binding to Lewis b antigen
Show others and affiliations
2004 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, Vol. 10, no 14, 2063-2066 p.Article in journal (Refereed) Published
Abstract [en]

Aim:To evaluate the effects of animal milk containing fucosylated antigens on Helicobacter pylori (H pylon) binding to Lewis b antigen.

Methods:A mammary gland expression vector containing human α1-3/4-fucosyltransferase cDNA sequences was constructed. Transient expression of human(α1-3/4-fucosyltransferase cDNA in goat mammary cell and establishment of transgenic mice were performed. The adhesion inhibitory properties of milk samples were analyzed by using Hpylori.

Results: Goat milk samples were found to inhibit bacterial binding to Lewis b antigen. The highest inhibition was observed 42 h after injection of the plasmid. The binding activity of Hpylori to Lewis b antigen reduced mostly, by 83%, however milk samples from transgenic mice did not inhibit Hpylori binding to Lewis b antigen.

Conclusion: The use of “humanized“ animal milk produced by the transgenic introduction of fucosylated antigen can perhaps provide an alternative therapy and preventive measure for Hpylori infection.

Place, publisher, year, edition, pages
Beijing: WJG Press , 2004. Vol. 10, no 14, 2063-2066 p.
Keyword [en]
Animals, Bacterial Adhesion, Blood Group Antigens/*metabolism, Female, Food; Genetically Modified, Fucosyltransferases/*genetics/metabolism, Gene Expression, Goats, Helicobacter pylori/*metabolism/physiology, Humans, Lewis Blood-Group System/*immunology, Mammary Glands; Animal/enzymology, Mice, Mice; Transgenic, Milk/enzymology/*physiology
URN: urn:nbn:se:umu:diva-6652PubMedID: 15237435OAI: diva2:146322
Available from: 2007-12-16 Created: 2007-12-16 Last updated: 2011-03-30Bibliographically approved

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Hammarström, LennartBorén, ThomasSjöström, Rolf
By organisation
Department of OdontologyOral Microbiology
In the same journal
World Journal of Gastroenterology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 80 hits
ReferencesLink to record
Permanent link

Direct link