Change search
ReferencesLink to record
Permanent link

Direct link
Sympathetic activation and inflammatory response in patients with subarachnoid haemorrhage.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
Show others and affiliations
2006 (English)In: Intensive Care Medicine, ISSN 0342-4642, Vol. 32, no 12, 1955-61 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The aim of this study was to evaluate the correlation between sympathetic nervous activation and the immune response in patients following subarachnoid haemorrhage (SAH). DESIGN AND SETTING: Clinical study in a neurosurgical intensive care unit. PATIENTS AND PARTICIPANTS: Fourteen patients with acute non-traumatic SAH were included. Fifteen healthy, age-matched volunteers served as controls for measurement of catecholamine spillover. INTERVENTION: Blood sampling for C3a, C5b-9, IL-6, IL-8 and norepinephrine kinetic determination was made within 48 h, at 72 h and on the 7th-10th day after the SAH. MEASUREMENTS AND RESULTS: SAH patients exhibited a profound increase in the rate of norepinephrine spillover to plasma at 48 h, 72 h and 7-10 days after the insult, 3-4 times that in healthy individuals. The plasma levels of C3a, IL-6 and C5b-9 were significantly elevated at 48 h, at 72 h and 7-10 days after the SAH, but the plasma level of IL-6 decreased significantly 7-10 days after the SAH. There was no relationship between the magnitude of sympathetic activation and the levels of inflammatory markers. CONCLUSIONS: Following SAH a pronounced activation of the sympathetic nervous system and the inflammatory system occurs. The lack of significant association between the rate of spillover of norepinephrine to plasma and the plasma levels of inflammatory markers indicates that the two processes, sympathetic activation and the immune response, following SAH are not quantitatively linked. In spite of a persistent high level of sympathetic activation the plasma level of IL-6 decreased significantly one week after SAH.

Place, publisher, year, edition, pages
2006. Vol. 32, no 12, 1955-61 p.
Keyword [en]
Adult, Aged, Case-Control Studies, Cytokines/*blood, Female, Humans, Intensive Care Units, Male, Middle Aged, Norepinephrine/*blood, Subarachnoid Hemorrhage/*blood/immunology, Sympathetic Nervous System/immunology/metabolism
URN: urn:nbn:se:umu:diva-6827PubMedID: 17058068OAI: diva2:146497
Available from: 2007-12-18 Created: 2007-12-18 Last updated: 2010-06-08Bibliographically approved

Open Access in DiVA

fulltext(113 kB)277 downloads
File information
File name FULLTEXT01.pdfFile size 113 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links


Search in DiVA

By author/editor
Naredi, Silvana
By organisation

Search outside of DiVA

GoogleGoogle Scholar
Total: 277 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 40 hits
ReferencesLink to record
Permanent link

Direct link