Iron supplements reduce erythrocyte copper-zinc superoxide dismutase activity in term, breastfed infants.
2005 (English)In: Acta Paediatr, ISSN 0803-5253, Vol. 94, no 11, 1578-82 p.Article in journal (Refereed) Published
AIM: To investigate whether iron supplements compromise copper status in infants. METHODS: 214 healthy, term, breastfed Swedish and Honduran infants were randomized to (1) iron supplements (1 mg/kg/d) from 4-9 mo of age, (2) iron supplements from 6-9 mo, or (3) placebo. Blood samples were obtained at 4, 6, and 9 mo and analyzed for plasma copper (p-Cu) and, at 9 mo, for copper/zinc-dependent superoxide dismutase (CuZn-SOD) activity. RESULTS: P-Cu increased with infant age. At 9 mo, Honduran infants had significantly higher p-Cu (1.40+/-0.29 vs 1.09+/-0.22 mg/l, p<0.001) and CuZn-SOD activity (1.09+/-0.29 vs 0.93+/-0.21 U/mg Hb, p<0.001) than Swedish infants. Infants receiving iron supplements from 4-9 mo had significantly lower CuZn-SOD at 9 mo of age (0.95+/-0.27 vs 1.08+/-0.24 U/mg Hb, p=0.023) than those receiving placebo.CONCLUSION: There is a physiologic increase in p-Cu during the first 9 mo of life. Differences in copper status between Swedish and Honduran infants may be due to genetic or nutritional differences. Iron supplementation decreases CuZn-SOD activity, probably due to a negative effect on copper status. Possible clinical implications remain to be elucidated.
Place, publisher, year, edition, pages
2005. Vol. 94, no 11, 1578-82 p.
Adult, Age Factors, Breast Feeding, Copper/*blood, Cross-Cultural Comparison, Dietary Supplements/*adverse effects, Female, Ferrous Compounds/*adverse effects, Honduras, Humans, Infant, Linear Models, Male, Multivariate Analysis, Superoxide Dismutase/*blood/drug effects, Sweden
IdentifiersURN: urn:nbn:se:umu:diva-7013PubMedID: 16303697OAI: oai:DiVA.org:umu-7013DiVA: diva2:146684