Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study.
2007 (English)In: Blood, ISSN 0006-4971, Vol. 109, no 11, 4641-7 p.Article in journal (Refereed) Published
Monosomy 7 (-7) and deletion 7q \del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations \+/- other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 +/- other compared with del(7q) +/- other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) +/- other compared with -7 +/- other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML \t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or + 21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future risk-group stratification.
Place, publisher, year, edition, pages
2007. Vol. 109, no 11, 4641-7 p.
Adolescent, Child, Chromosome Aberrations, Chromosomes; Human; Pair 7, Female, Gene Deletion, Humans, International Cooperation, Leukemia; Myeloid; Acute/*genetics/*mortality, Male, Monosomy, Remission Induction, Retrospective Studies, Stem Cell Transplantation, Translocation; Genetic
IdentifiersURN: urn:nbn:se:umu:diva-7073PubMedID: 17299091OAI: oai:DiVA.org:umu-7073DiVA: diva2:146744