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Fecal calprotectin in very low birth weight infants.
Umeå University, Faculty of Medicine, Clinical Sciences, Paediatrics.
2007 (English)In: J Pediatr Gastroenterol Nutr, ISSN 1536-4801, Vol. 44, no 4, 407-13 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To measure concentrations of fecal calprotectin (f-calprotectin) in infants with very low birth weight (VLBW; <1500 g) longitudinally and to describe changes in f-calprotectin in infants who develop severe abdominal disease. PATIENTS AND METHODS: The study included 59 VLBW infants. Seven patients (disease group) developed severe abdominal disease defined as necrotizing enterocolitis (NEC) or a condition leading to laparotomy. The remainder (n = 52) were considered reference infants and had a mean (+/-SD) gestational age of 27.2 +/- 2.6 weeks and a birth weight of 939 +/- 273 g. F-calprotectin was analyzed in meconium and weekly during postnatal weeks 1 to 8. In disease cases, more frequent samples were analyzed around the time of abdominal disease diagnosis. RESULTS: In reference infants the median (range) f-calprotectin level in meconium was 332 (12-9386) microg/g and correlated negatively to Apgar score. F-calprotectin in postmeconium samples was 253 (9-1867) microg/g and correlated positively to delivery by cesarean section, postnatal age, and volume of enteral feeds, and negatively to treatment with antibiotics and corticosteroids. In reference infants no postmeconium sample had f-calprotectin levels >2000 microg/g. In disease cases f-calprotectin was increased to >2000 microg/g in 3 cases of NEC and 1 case of covered perforation with microscopic bowel inflammation. In 1 case of NEC without microscopic bowel inflammation and 2 cases of focal intestinal perforation, f-calprotectin levels never exceeded 2000 microg/g. CONCLUSIONS: F-calprotectin concentrations in VLBW infants are similar to previously reported levels in healthy term and moderately preterm infants. An f-calprotectin level >2000 microg/g is a useful but not an early marker of NEC and other severe intestinal inflammatory conditions in VLBW infants.

Place, publisher, year, edition, pages
2007. Vol. 44, no 4, 407-13 p.
Keyword [en]
Biological Markers/analysis, Enterocolitis; Necrotizing/diagnosis, Feces/*chemistry, Female, Gastrointestinal Diseases/*diagnosis, Humans, Infant; Newborn, Infant; Very Low Birth Weight, Leukocyte L1 Antigen Complex/*analysis, Male, Meconium/chemistry
URN: urn:nbn:se:umu:diva-7078PubMedID: 17414135OAI: diva2:146749
Available from: 2008-01-12 Created: 2008-01-12 Last updated: 2011-01-11Bibliographically approved

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