Analysis of the dose-response of N-acetylcysteine in the prevention of sensory neuronal loss after peripheral nerve injury
2007 (English)In: How to Improve the Results of Peripheral Nerve Surgery / [ed] H. Millesi, R. Schmidhammer, Springer, 2007, Vol. 100, 29-31 p.Chapter in book (Other academic)
BACKGROUND: N-Acetylcysteine (NAC) is a safe pharmaceutical agent known to protect cells from oxidative damage. Following peripheral nerve transection, NAC has been found to eliminate sensory neuronal loss. This study examines the dose-response relationship of NAC in preventing neuronal death. METHODS AND FINDINGS: The rat sciatic nerve transection model was used, and stereological quantification of sensory neuron survival carried out at two weeks post-axotomy. NAC was administered systemically as an intraperitoneal injection to five groups of rats at a range of doses (1-300 mg/kg/day). Significant neuronal loss was observed in the 1 mg/kg/day dosage group (18.5% loss, p = 0.067 vs. sham treatment). A degree of neuroprotection occurred with 10 mg/kg/day (9.1% loss, p < 0.005 vs. control), whilst there was no significant loss with either 150 or 300 mg/kg/day. CONCLUSIONS: The prevention of sensory neuronal loss with NAC is dose dependent and effective over a wide therapeutic range. This analysis confirms the efficacy of systemic administration and provides a dose framework with which NAC has clinical potential to improve outcome after peripheral nerve trauma.
Place, publisher, year, edition, pages
Springer, 2007. Vol. 100, 29-31 p.
, Acta Neurochirurgica Supplementum, ISSN 0065-1419 ; 100
Acetylcysteine/*administration & dosage/pharmacology, Animals, Cell Count, Dose-Response Relationship; Drug, Ganglia; Spinal/drug effects/pathology, Neurons; Afferent/*drug effects/*pathology, Rats, Sciatic Nerve/drug effects/*injuries/*pathology, Wounds and Injuries/pathology
IdentifiersURN: urn:nbn:se:umu:diva-8122DOI: 10.1007/978-3-211-72958-8_6ISI: 000271635700006PubMedID: 17985540ISBN: 978-3-211-72955-7 (Print)ISBN: 978-3-211-72958-8 (Online)OAI: oai:DiVA.org:umu-8122DiVA: diva2:147793