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Are neurotrophins important in ulcerative colitis?
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
2007 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1107, 290-299 p.Article in journal (Other academic) Published
Abstract [en]

Neurotrophins are known to have growth, survival-promoting, and healing effects. The importance of neurotrophins in ulcerative colitis (UC) is, however, unclear. Recent studies in our group revealed that an occurrence of marked changes in neurotrophin expression patterns was related to a worsening of the disease process. There was thus an upregulation for the lamina propria cells but a downregulation in nerve structures concerning neurotrophin expressions in severe UC. The observations show that changes in the neurotrophin system are a part of the disease process in UC and are of interest as treatments interfering with neurotrophin effects in other situations have been found to have trophic and healing effects.

Place, publisher, year, edition, pages
New York: New York Academy of Sciences , 2007. Vol. 1107, 290-299 p.
Keyword [en]
Animals, Colitis; Ulcerative/*metabolism/pathology/therapy, Cytokines/metabolism, Humans, Nerve Growth Factors/*metabolism, Receptor; Nerve Growth Factor/metabolism
Identifiers
URN: urn:nbn:se:umu:diva-8142DOI: 10.1196/annals.1381.031PubMedID: 17804557OAI: oai:DiVA.org:umu-8142DiVA: diva2:147813
Available from: 2008-01-15 Created: 2008-01-15 Last updated: 2012-10-10Bibliographically approved

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Norrgård, ÖrjanForsgren, Sture

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