Decrease in binding for the neuropeptide VIP in response to marked inflammation of the mucosa in ulcerative colitis
2007 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1107, 280-289 p.Article in journal (Other academic) Published
The neuropeptide vasoactive intestinal peptide (VIP) is involved in the neuroimmunomodulation of the intestine. In the present study, specimens from the sigmoid colon of ulcerative colitis (UC) and non-UC patients were examined for immunohistochemistry and in vitro receptor autoradiography. Marked occurrence of VIP binding was observed in the mucosa. However, there were very low levels of binding in areas showing pronounced inflammation/derangement. The study shows that marked derangement of the mucosa leads to a distinct decrease in VIP binding. Thus, it is possible that a decrease in trophic and anti-inflammatory VIP effects occurs in areas exhibiting a very marked inflammation.
Place, publisher, year, edition, pages
2007. Vol. 1107, 280-289 p.
adult, aged, aged; 80 and over, autoradiography, biological markers, colitis, ulcerative/metabolism/pathology, female, gastric mucosa/metabolism/pathology, humans, immunohistochemistry, inflammation/metabolism/pathology, intestinal mucosa/metabolism/pathology, male, middle aged, receptors, vasoactive intestinal peptide/metabolism, vasoactive intestinal peptide/metabolism
IdentifiersURN: urn:nbn:se:umu:diva-8144DOI: 10.1196/annals.1381.030PubMedID: 17804556OAI: oai:DiVA.org:umu-8144DiVA: diva2:147815