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T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis
Umeå University, Faculty of Science and Technology, Chemistry.
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2000 (English)In: Arthritis Research & Therapy, Vol. 2, no 4, 315-26 p.Article in journal (Refereed) Published
Abstract [en]

The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as IFN-γ secretion and ability to provide B cell help. These mice were still susceptible to CIA. The response was mainly directed to the glycosylated form of the CII 256-270 peptide, rather than to the nonglycosylated peptide. Tolerance induction was rapid; transferred T cells encountered CII within a few days. CII immunization several weeks after thymectomy of the mice did not change their susceptibility to arthritis or the induction of partial T-cell tolerance, excluding a role for recent thymic emigrants. Thus, partially tolerant CII autoreactive T cells are maintained and are crucial for the development of CIA.

Place, publisher, year, edition, pages
2000. Vol. 2, no 4, 315-26 p.
URN: urn:nbn:se:umu:diva-8450DOI: doi:10.1186/ar106OAI: diva2:148121
Available from: 2008-01-22 Created: 2008-01-22 Last updated: 2011-01-14Bibliographically approved

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