No difference in symptoms of irritable bowel syndrome between healthy subjects and patients with recurrent depression in remission
2007 (English)In: Neurogastroenterology and Motility, ISSN 1350-1925, E-ISSN 1365-2982, Vol. 19, no 11, 896-904 p.Article in journal (Refereed) Published
There is bidirectional comorbidity between anxiety/depression and irritable bowel syndrome (IBS). To investigate the prevalence of IBS symptoms, and factors associated with gastrointestinal symptoms in patients with recurrent depressive disorder. Patients (n = 95) with recurrent type of major depression according to DSM-IV criteria and sex- and age-matched controls (n = 190) were sent questionnaires investigating symptoms of IBS [Gastrointestinal Symptom Rating Scale (GSRS)-IBS] and symptoms of anxiety and depression [Hospital Anxiety and Depression Scale (HADS)]. Medical records were checked over a 10-year period for chronic somatic symptoms or diseases. Seventy-three patients with unipolar disorder (mean age 63.6 years SD 13.8; range 23–86 years) and 156 controls (mean age 59.2 years SD 11.6, range 21–85 years) responded. Patients with recurrent depression had higher GSRS-IBS scores and showed a strong correlation between symptoms of IBS and anxiety-depression (rs = 0.54; P < 0.001). IBS symptoms were also associated with multiple pain symptoms, higher health-seeking behaviour and selective-serotonin-reuptake inhibitor intake. However, patients with recurrent depression (n = 46) in remission (HADS-Depression score <8) did not have more symptoms of IBS than controls (GSRS-IBS median score 6.0 vs 6.5; P = 0.46). There is a strong association between symptoms of IBS and symptoms of anxiety and depression, whereas depressive patients in remission do not have more IBS symptoms than controls.
Place, publisher, year, edition, pages
Oxford: Blackwell , 2007. Vol. 19, no 11, 896-904 p.
adult, aged, aged; 80 and over, anxiety/complications/physiopathology, case-control studies, depression/*complications/*physiopathology/psychology, female, health surveys, humans, irritable bowel syndrome/*complications/*physiopathology/psychology, male, middle aged, prevalence, recurrence, remission; spontaneous, severity of illness index
IdentifiersURN: urn:nbn:se:umu:diva-8752DOI: doi:10.1111/j.1365-2982.2007.00967.xPubMedID: 17973640OAI: oai:DiVA.org:umu-8752DiVA: diva2:148423