Possible release of an ArgGlyArgProGln pentapeptide with innate immunity properties from acidic proline-rich proteins by proteolytic activity in commensal streptococcus and actinomyces species.
2000 (English)In: Infection and Immunity, ISSN 0019-9567, Vol. 68, no 9, 5425-9 p.Article in journal (Refereed) Published
This study suggests degradation of salivary acidic proline-rich proteins (PRPs) into potential innate-immunity-like peptides by oral Streptococcus and Actinomyces species. PRP degradation paralleled cleavage of Pro-containing substrates. PRP degradation by S. gordonii strain SK12 instantly released a Pyr(1)-Pro(104)Pro(105) and a Gly(111)-Pro(149)Gln(150) peptide together with a presumed Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) pentapeptide. The synthetic Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) peptide desorbed bound bacteria and counteracted sucrose-induced decrease of dental plaque pH in vitro.
Place, publisher, year, edition, pages
2000. Vol. 68, no 9, 5425-9 p.
IdentifiersURN: urn:nbn:se:umu:diva-8889PubMedID: 10948176OAI: oai:DiVA.org:umu-8889DiVA: diva2:148560