umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rat salivary gland function after fractionated irradiation.
Umeå University, Faculty of Medicine, Odontology, Cariology.
Show others and affiliations
1997 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 36, no 2, 191-198 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate longitudinal effects of fractionated irradiation, with various total doses, on salivary gland function in the rat. Female Sprague-Dawley rats were irradiated with 4, 5, 6, 7 or 8 Gy per day on five consecutive days. Irradiation was given to the head and neck region. Whole saliva was collected before and 2, 15 and 26 weeks after irradiation. In general the effects of irradiation on salivary gland function were found to be related to dose and time after exposure. Secretion rates were significantly decreased two weeks after irradiation with doses of 30 Gy or higher, after 15 weeks with 25 Gy or higher, and after 26 weeks with 20 Gy or higher. Response patterns to irradiation differed between the salivary constituents. Thus, the conclusions from this study are that early and late effects display different patterns and that the model used to study variations in salivary gland function after fractionated irradiation must be adjusted to the question addressed.

Place, publisher, year, edition, pages
1997. Vol. 36, no 2, 191-198 p.
Identifiers
URN: urn:nbn:se:umu:diva-8954PubMedID: 9140437OAI: oai:DiVA.org:umu-8954DiVA: diva2:148625
Available from: 2008-02-22 Created: 2008-02-22 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Fractionated irradiation of salivary glands: loss and protection of function
Open this publication in new window or tab >>Fractionated irradiation of salivary glands: loss and protection of function
1995 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Radiotherapy of malignancies in the head and neck often involves the major and minor salivary glands in the radiation field. Adverse effects, such as dry mouth symptoms, are common after such therapy. The aim of this thesis was to study longitudinal effects of fractionated irradiation to the head and neck on salivary gland function in man and in the rat and to test radioprotection from antioxidant vitamins (retinol, a-tocopherol and ^-carotene).

A sharp decrease in parotid saliva flow rate was seen after one week of irradiation in cancer patients, but in some patients recovery was seen two months after completed treatment. Loss and recovery of salivary gland function were dependent on the total dose given. Irradiation with doses of >65 Gy to the parotid glands led to permanent loss of function in the majority of parotid glands, while recovery could be seen after irradiation with doses of <52 Gy. Concentrations of some proteins and electrolytes in saliva were increased during irradiation but no changes remained 18 months after radiotherapy. However, large inter-individual differences were seen.

The irradiation effects observed in rats did not greatly differ from those seen in humans, but no recovery of salivary gland function was seen. On the one hand the impairments of saliva flow and composition w ere dose and time dependent, but on the other hand the response pattem differed between salivary components. Morphological alterations were not seen in the rat salivary' glands after tw'O or five weeks but 26 weeks after irradiation. No single model seems to be optimal for studying all parameters. Therefore, to study effects on salivary glands after irradiation the rat model must be adjusted to meet the questions addressed. Supplementation with vitamin A provided no radioprotection, whereas it w'as found that supplementation with a-tocopherol (3.4 mg/day) and ß-carotene (6 mg/day) during irradiation reduced the degree of inflammation and partly preserved salivary gland function. It did not, however, lead to morphometrically detectable differences in proportions of acinar or ductal cells or stroma.Keywords: Irradiation, salivary glands, saliva composition, antioxidants

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 1995. 82 p.
Series
Umeå University odontological dissertations, ISSN 0345-7532 ; 52
Keyword
Irradiation, salivary glands, saliva composition, antioxidants, radioprotection
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-100594 (URN)91-7191-047-6 (ISBN)
Public defence
1995-06-02, Föreläsningssal B, Tandläkarhögskolan 9 tr, NUS, Umeå universitet, Umeå, 09:00
Supervisors
Projects
digitalisering@umu
Note

S. 1-82: sammanfattning, s. 85-152: 6 uppsatser

Available from: 2015-03-16 Created: 2015-03-04 Last updated: 2015-04-08Bibliographically approved

Open Access in DiVA

No full text

PubMed

Search in DiVA

By author/editor
Johansson, Ingegerd
By organisation
Cariology
In the same journal
Acta Oncologica

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 30 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf