Synthesis and absolute configuration of methyl (-)-(3R)-8-(4-bromophenyl)-7-(naphthalen-1-ylmethyl)-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylate
2002 (English)In: Acta Crystallographica Section E: Structure Reports Online, ISSN 1600-5368, E-ISSN 1600-5368, Vol. 58, no 8, 812-814 p.Article in journal (Refereed) Published
The title molecule, C26H20BrNO3S, contains a ring-fused 2-pyridinone framework substituted with a 4-bromo-phenyl-, a naphthalen-1-ylmethyl and a methoxycarbonyl substituent. The main goal of this work was to confirm the stereochemistry for the methoxycarbonyl substituent, which proved to be 3R. Moreover, the 4-bromophenyl substituent was shown to be rotated out of the plane of the 2-pyridinone ring, with a torsion angle of 61.2 (5)°. To allow the best packing arrangement, the naphthalen-1-ylmethyl substituent is positioned to mediate an intermolecular - interaction.
Place, publisher, year, edition, pages
2002. Vol. 58, no 8, 812-814 p.
IdentifiersURN: urn:nbn:se:umu:diva-9050DOI: 10.1107/S1600536802011480OAI: oai:DiVA.org:umu-9050DiVA: diva2:148721