A review of environmental toxicant analysis by using multidimensional gas chromatography and comprehensive GC
2003 (English)In: Clinica Chimica Acta, Vol. 328, no 1-2, 1-19 p.Article in journal (Refereed) Published
The purpose of this review is to highlight the developments in coupled-column gas chromatography methods for qualitative analysis of selected environmental toxicants such as dioxin, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), etc. In particular, the new technique of GC×GC will be introduced, and its role, and the promise it offers to this field is discussed. The benefits of enhanced separation to quantitative analysis will be considered.
In order to perform an accurate risk assessment, both the dose and biological effects of environmental toxicants have to be determined with a high degree of certainty. This is most often achieved by using chromatographic methods. Given the complexity of most environmental sample extracts, single-column gas chromatography is unable to fully resolve all the components of interest frequently leading to a positive bias in the reported concentrations. Advanced separation tools, such as multidimensional gas chromatography (MDGC), were investigated quite early and demonstrated improvements in separation. However, limitations in the number of target analytes that could be analyzed in a single run as well as insufficient robustness lead to a continued interest in alternative solutions. The parallel development of mass spectrometric identification and quantification strategies proved useful in many cases, although it frequently failed to provide positive identification of chromatographically unresolved isomeric compounds. More recently, comprehensive two-dimensional gas chromatography (GC×GC) may offer a solution to that problem, especially because it offers enhanced resolution for complex mixtures containing trace level environmental toxicants.
Place, publisher, year, edition, pages
2003. Vol. 328, no 1-2, 1-19 p.
Toxic environmental pollutants, Multidimensional gas chromatography, GC-MS, GC×GC
IdentifiersURN: urn:nbn:se:umu:diva-9219DOI: doi:10.1016/S0009-8981(02)00382-0OAI: oai:DiVA.org:umu-9219DiVA: diva2:148890