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The Common D302H Variant of CASP8 Is Associated with Risk of Glioma.
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2008 (English)In: Cancer Epidemiol Biomarkers Prev, ISSN 1055-9965, Vol. 17, no 4, 987-989 p.Article in journal (Refereed) Published
Abstract [en]

Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.

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2008. Vol. 17, no 4, 987-989 p.
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URN: urn:nbn:se:umu:diva-9507DOI: doi:10.1158/1055-9965.EPI-07-2807PubMedID: 18398042OAI: oai:DiVA.org:umu-9507DiVA: diva2:149178
Available from: 2008-04-14 Created: 2008-04-14 Last updated: 2011-08-25Bibliographically approved

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Malmer, BeatriceHenriksson, Roger

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