Change search
ReferencesLink to record
Permanent link

Direct link
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.
Show others and affiliations
2008 (English)In: Cancer Epidemiol Biomarkers Prev, ISSN 1055-9965, Vol. 17, no 5, 1195-1202 p.Article in journal (Refereed) Published
Abstract [en]

Folate metabolism plays an important role in carcinogenesis. To test the hypothesis that polymorphic variation in the folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) influences the risk of primary brain tumors, we genotyped 1,005 glioma cases, 631 meningioma cases, and 1,101 controls for the MTHFR C677A and A1298C, MTRR A66G, and MTR A2756G variants. MTHFR C677T-A1298C diplotypes were associated with risk of meningioma (P = 0.002) and glioma (P = 0.02); risks were increased with genotypes associated with reduced MTHFR activity. The highest risk of meningioma was associated with heterozygosity for both MTHFR variants [odds ratio (OR), 2.11; 95% confidence interval (95% CI), 1.42-3.12]. The corresponding OR for glioma was 1.23 (95% CI, 0.91-1.66). A significant association between risk of meningioma and homozygosity for MTRR 66G was also observed (OR, 1.41; 95% CI, 1.02-1.94). Our findings provide support for the role of folate metabolism in the development of primary brain tumors. In particular, genotypes associated with increased 5,10-methylenetetrahydrofolate levels are associated with elevated risk.

Place, publisher, year, edition, pages
2008. Vol. 17, no 5, 1195-1202 p.
URN: urn:nbn:se:umu:diva-9690DOI: doi:10.1158/1055-9965.EPI-07-273PubMedID: 18483342OAI: diva2:149361
Available from: 2008-05-20 Created: 2008-05-20 Last updated: 2011-08-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Malmer, BeatriceHenriksson, Roger
By organisation

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link