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Altered deactivation in individuals with genetic risk for Alzheimer's disease.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
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2008 (English)In: Neuropsychologia, ISSN 0028-3932, Vol. 46, no 6, 1679-1687 p.Article in journal (Refereed) Published
Abstract [en]

Regions that show task-induced deactivations may be part of a default-mode network related to processes that are more engaged during passive than active task conditions. Alteration of task-induced deactivations with age and dementia is indicated by atypical engagement of default-mode network regions. Genetic studies show a relation between the apolipoprotein E4 (APOE4) allele and the common form of Alzheimer's disease (AD), and altered functional brain activation has been observed in non-demented APOE4 carriers compared to non-carriers. Here we investigate the hypothesis of altered default-mode network brain responses in individuals with genetic risk for AD. Functional MRI was used to assess task-induced deactivation in 60 subjects of which 30 carried at least one copy of the APOE4 allele, and 30 non-carriers. Subjects were scanned while performing a semantic categorization task shown to promote episodic memory encoding. The results show patterns of deactivation consistent with the default-mode network. We also found reduced deactivation in non-demented APOE4 carriers compared to non-carriers, suggesting alterations in the default-mode network in the absence of dementia. These results implicate possibilities for investigating altered properties of task-induced deactivations in individuals with genetic risk for AD, and may prove useful for pre-clinical identification of individuals susceptible to memory problems and AD.

Place, publisher, year, edition, pages
2008. Vol. 46, no 6, 1679-1687 p.
Keyword [en]
Deactivation, aging, APOE, genetic, AD, Alzheimer's disease, fMRI, compensation, memory encoding
URN: urn:nbn:se:umu:diva-10001DOI: doi:10.1016/j.neuropsychologia.2008.01.026PubMedID: 18346764OAI: diva2:149672
Available from: 2008-06-04 Created: 2008-06-04 Last updated: 2011-05-17Bibliographically approved

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Larsson, AnneAdolfsson, RolfNyberg, Lars
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Radiation PhysicsPsychiatryDiagnostic RadiologyDepartment of Integrative Medical Biology (IMB)

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