Maternal transfer of brominated flame retardants in zebrafish (Danio rerio).
2008 (English)In: Chemosphere, ISSN 0045-6535, Vol. 73, no 2, 203-8 p.Article in journal (Refereed) Published
In many species reproduction and embryonic development have been shown to be sensitive to environmental contaminants. Understanding embryonic exposure to environmental contaminants is thus highly important. In this study concentrations of brominated flame retardants (BFRs) were measured in zebrafish eggs after parental exposure for 42 days via the diet. Zebrafish were exposed to two doses of eleven structurally-diverse BFRs. Eight BFRs were detected in the female zebrafish and maternal transfer to eggs was evident for all eight compounds. The highest concentrations in eggs were observed for hexabromocyclododecane (HBCD) and 2,4,4′-tribromodiphenyl ether (BDE 28), followed by 2,2′,3,4,4′,5′,6-heptabromodiphenyl ether (BDE 183) and tetrabromobisphenol A 2,3-dibromopropyl ether (TBBPA DBPE). Five potential BFR metabolites were tentatively identified in female fish and maternal transfer was observed also for these compounds. The lipid adjusted concentrations in eggs were significantly higher than the concentrations in female fish for several of the BFRs. Further, the results showed a generally higher transfer in the lower exposure level and also indicated a dependency on the physico-chemical properties of the compounds.
Place, publisher, year, edition, pages
2008. Vol. 73, no 2, 203-8 p.
Maternal transfer, Dietary Exposure, Zebrafish, Egg, Brominated flame retardants
IdentifiersURN: urn:nbn:se:umu:diva-10113DOI: doi:10.1016/j.chemosphere.2008.04.033PubMedID: 18514256OAI: oai:DiVA.org:umu-10113DiVA: diva2:149784
Brominated Flame Retardants (BFRs) - Papers presented at the Fourth International Symposium, BFR2007, held in Amsterdam, The Netherlands 24-27 April 20072008-09-022008-09-022010-01-15Bibliographically approved