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Synthesis of a novel tricyclic peptidomimetic Scaffold
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
2008 (English)In: Organic Letters, Vol. 10, no 18, 4005-4007 p.Article in journal (Refereed) Published
Abstract [en]

An efficient method to synthesize a novel rigid tricyclic peptidomimetic scaffold through ring-closure of amino-functionalized bicyclic 2-pyridones has been discovered. The scaffold can function as a peptide backbone mimetic (highlighted) with two substituents independently variable to fine-tune biological response. Halogenation of the pyrazolo ring followed by Suzuki couplings made it possible to introduce substituents with variable electronic properties late in the synthetic route, which is preferable in library synthesis.

Place, publisher, year, edition, pages
2008. Vol. 10, no 18, 4005-4007 p.
National Category
Chemical Sciences
URN: urn:nbn:se:umu:diva-10351DOI: 10.1021/ol801506yOAI: diva2:150022
Available from: 2008-10-13 Created: 2008-10-13 Last updated: 2012-04-05Bibliographically approved
In thesis
1. Development of 2-Pyridone-based central fragments: Affecting the aggregation of amyloid proteins
Open this publication in new window or tab >>Development of 2-Pyridone-based central fragments: Affecting the aggregation of amyloid proteins
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

There are many applications of small organic compounds, e.g. as drugs or as tools to study biological systems. Once a compound with interesting biological activity has been found, medicinal chemists typically synthesize small libraries of compounds with systematic differences to the initial “hit” compound. By screening the new ensemble of compounds for their ability to perturb the biological system, insights about the system can be gained. In the work presented here, various ways to synthesize small libraries of ring-fused 2‑pyridones have been developed. Members of this class of peptidomimetic compounds have previously been found to have a variety of biological activities, e.g. as antibacterial agents targeting virulence, and as inhibitors of the aggregation of Alzheimer b‑peptides. The focus in this work has been to alter the core skeleton, the central fragment, of the previously discovered biologically active 2‑pyridones and evaluate the biological effects of these changes. Several new classes of compounds have been constructed and their preparations have included the development of multi-component reactions and a method inspired by diversity-oriented synthesis.

Some of the new compounds have been evaluated for their effect on the fibrillation of different amyloid proteins. Both the Parkinson-associated amyloid protein a-synuclein and the bacterial protein CsgA that is involved in bacterial biofilm formation are affected by subtle changes of the compounds’ central fragments. This is an example of the usefulness of central-fragment alterations as a strategy to probe structure-activity relationships, and the derived compounds may be used as tools in further study of the aggregation of amyloid proteins.

Place, publisher, year, edition, pages
Umeå, Sweden: Umeå universitet, 2012. 60 p.
2-pyridone, central fragment alteration, multi-component reactions, directed diversity-oriented synthesis, peptidomimetics, amyloid, protein aggregation, pilicide, curlicide
National Category
Organic Chemistry
Research subject
Biorganic Chemistry
urn:nbn:se:umu:diva-53705 (URN)978-91-7459-417-1 (ISBN)
Public defence
2012-04-27, KBC-huset, KB3B1, Umeå universitet, Umeå, 10:00 (English)
Swedish Research Council, 621-2010-4730Knut and Alice Wallenberg Foundation
Available from: 2012-04-05 Created: 2012-04-04 Last updated: 2012-04-05Bibliographically approved

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Sellstedt, MagnusAlmqvist, Fredrik
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