Differences in expression of tumor markers between pre- and postmenopausal women with invasive cervical cancer.
2008 (English)In: Anticancer Res, ISSN 0250-7005, Vol. 28, no 3B, 1793-1795 p.Article in journal (Refereed) Published
THE AIM of the present study was to investigate the differences in the expression of tumor markers in squamous cell and in adenomatous carcinomas in pre- and postmenopausal women, respectively.
PATIENTS AND METHODS:
The study population comprised 53 premenopausal and 107 postmenopausal women. Thirty-four tumors were adenomatous (n=31) or adenosquamous carcinomas (n=3), distributed between 13 premenopausal and 21 postmenopausal women. The remaining 126 squamous cell carcinomas were diagnosed in 40 pre- and 86 postmenopausal women. Expression of ten tumor markers of possible clinical importance in cervical cancer was evaluated.
Expression of three tumor markers, p53 (>0% vs. 0%), p27 (> or =20% vs. <20%) and cyclooxygenase-2 (COX-2) (high intensity vs. moderate/none) differed significantly between pre- compared to postmenopausal women with squamous cell (p27; 54% vs. 72%, p=0.009) or adenomatous carcinomas (p53; 8% vs. 63%, p=0.006 and COX-2; 46% vs. 20%, p=0.03). All results were adjusted for clinical cancer stage.
The unusual age-specific incidence curve in cervical cancer has rarely been related to expression of tumor markers. Age-related differences in expression of tumor markers could reflect some age-related different biological mechanisms in cervical cancer.
Place, publisher, year, edition, pages
2008. Vol. 28, no 3B, 1793-1795 p.
Cervical cancer, markers, p53, p27, COX-2, Ki-67, EGFR, E-cadherin, c-myc, VEGF, CD44, CD4, age-specific expression
IdentifiersURN: urn:nbn:se:umu:diva-10410PubMedID: 18630462OAI: oai:DiVA.org:umu-10410DiVA: diva2:150081