Selective synthesis of 2-substituted pyridine N-oxides via directed ortho-metallation using Grignard reagents
2008 (English)In: Tetrahedron Letters, Vol. 49, no 48, 6901-3 p.Article in journal (Refereed) Published
Addition of i-PrMgCl to pyridine N-oxides in THF at −78 °C generates selectively an ortho-metallated species, which can be trapped with various electrophiles to generate 2-substituted pyridine N-oxides. Furthermore, by applying a double metal-catalyzed cross-coupling, direct arylation of the pyridine N-oxides is achieved.
Place, publisher, year, edition, pages
2008. Vol. 49, no 48, 6901-3 p.
IdentifiersURN: urn:nbn:se:umu:diva-10629DOI: doi:10.1016/j.tetlet.2008.09.104OAI: oai:DiVA.org:umu-10629DiVA: diva2:150300