Change search
ReferencesLink to record
Permanent link

Direct link
Sphingomyelin structure influences the lateral diffusion and raft formation in Lipid Bilayers
Umeå University, Faculty of Science and Technology, Chemistry.
Umeå University, Faculty of Science and Technology, Chemistry.
Umeå University, Faculty of Science and Technology, Chemistry.
2006 (English)In: Biophysical Journal, ISSN 0006-3495, Vol. 90, no 6, 2086-92 p.Article in journal (Refereed) Published
Abstract [en]

Liquid-disordered/liquid-ordered two-phase coexistence regions in hydrated bilayers have been investigated for sphingomyelins (SMs) of three different origins: egg, brain, and milk with the pulsed-field gradient NMR technique for lateral diffusion measurement. It is found that the three SMs have the same diffusional behavior in bilayers of SM alone, but in the multicomponent systems of dioleoylphosphatidylcholine/SM/cholesterol, the ability to form domains differs for the three SMs. The two-phase area is more extended for egg SM than for brain SM, and no two-phase coexistence is found for milk SM. The differences in behavior are correlated with the homogeneity of the SM hydrocarbon chain compositions, in which egg SM has the most homogeneous and milk SM has the most heterogeneous composition. The results indicate that a crucial element in the domain-forming process is the formation of highly packed bilayers of SM and cholesterol rather than specific interactions between SM and cholesterol.

Place, publisher, year, edition, pages
2006. Vol. 90, no 6, 2086-92 p.
Keyword [en]
Diffusion, Lipid Bilayers/*chemistry, Membrane Fluidity, Membrane Microdomains/*chemistry, Molecular Conformation, Molecular Structure, Phase Transition, Sphingomyelins/*chemistry
URN: urn:nbn:se:umu:diva-10827DOI: doi:10.1529/biophysj.105.075150PubMedID: 16387761OAI: diva2:150498
Available from: 2007-05-29 Created: 2007-05-29 Last updated: 2011-01-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Filippov, AndreyOrädd, GregerLindblom, Göran
By organisation

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 27 hits
ReferencesLink to record
Permanent link

Direct link