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Definition of Drosophila hemocyte subsets by cell-type specific antigens.
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2007 (English)In: Acta Biol Hung, ISSN 0236-5383, Vol. 58 Suppl, 95-111 p.Article in journal (Refereed) Published
Abstract [en]

We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. On the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmatocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged in four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocytes.

Place, publisher, year, edition, pages
2007. Vol. 58 Suppl, 95-111 p.
Keyword [en]
Animals, Antibodies; Monoclonal/immunology, Antigens/*immunology, Blotting; Western, Cell Compartmentation, Drosophila, Female, Flow Cytometry, Fluorescent Antibody Technique; Indirect, Hemocytes/*classification/immunology, Mice, Mice; Inbred BALB C, Phagocytosis
URN: urn:nbn:se:umu:diva-11261PubMedID: 18297797OAI: diva2:150932
Available from: 2008-12-03 Created: 2008-12-03 Last updated: 2011-01-11Bibliographically approved

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Hultmark, D
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Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Medicine)

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