umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide
Umeå University, Faculty of Medicine, Department of Odontology, Oral Cell Biology.
Umeå University, Faculty of Medicine, Department of Odontology, Oral Cell Biology.
2008 (English)In: Journal of Musculoskeletal and Neuronal Interactions - JMNI, ISSN 1108-7161, Vol. 8, no 2, 154-165 p.Article in journal (Refereed) Published
Abstract [en]

Immunohistochemical phenotypic characterization of skeletal nerve fibers has demonstrated the expression of a restricted number of neuropeptides, including calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal peptide (VIP). According to the neuro-osteological hypothesis, such neuropeptides can be released and exert paracrine biological effects on bone cells present close to the nerve endings expressing these signaling molecules. The existence of such interplay is most convincingly shown by the hypothalamic control of bone formation, in the case of leptin stimulation of hypothalamic nuclei mediated by the sympathetic nervous system and inhibitory beta-adrenergic receptors on osteoblasts. In addition to these receptors, osteoblasts and osteoclasts express functional receptors for CGRP, SP and VIP, which can regulate both bone formation and bone resorption. The evidence for these observations is summarized in the present paper.

Place, publisher, year, edition, pages
2008. Vol. 8, no 2, 154-165 p.
Identifiers
URN: urn:nbn:se:umu:diva-11301PubMedID: 18622084OAI: oai:DiVA.org:umu-11301DiVA: diva2:150972
Available from: 2008-12-09 Created: 2008-12-09 Last updated: 2017-12-14Bibliographically approved

Open Access in DiVA

No full text

Other links

PubMedFulltext

Search in DiVA

By author/editor
Lerner, Ulf H
By organisation
Oral Cell Biology
In the same journal
Journal of Musculoskeletal and Neuronal Interactions - JMNI

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 48 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf