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Bacterial and mammalian cell response to poly(3-sulfopropyl methacrylate) brushes loaded with silver halide salts
Umeå University, Faculty of Science and Technology, Chemistry.
Umeå University, Faculty of Science and Technology, Chemistry.
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Pulmonary Medicine.
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2009 (English)In: Biomaterials, Vol. 30, no 8, 1524-31 p.Article in journal (Refereed) Published
Abstract [en]

This study investigates the antibacterial and cytotoxic effect of surfaces with sulphonate brushes containing silver salts. By using the same type of samples for both cytotoxicity and antibacterial studies, these two parameters could be compared in a controlled way. The silver was incorporated into the brush in four different forms to enable release of silver ions at different concentrations and different rates. It was found that although the surfaces displayed very good antibacterial properties in buffer solutions, this effect disappeared in systems with high protein content. Similarly, the silver-containing surfaces displayed cytotoxic effects in the absence of serum proteins but this effect was reduced in the presence of serum. The speciation of silver in the different solutions is discussed. Cytotoxic and antibacterial effects are compared at the different silver concentrations released. The implications of a concentration range where silver could be used to kill bacterial without harmful effects on mammalian cells are also discussed and questioned.

Place, publisher, year, edition, pages
2009. Vol. 30, no 8, 1524-31 p.
Keyword [en]
Antibacterial, Cytotoxic, Surface modification, Metal ion release, Silver
Identifiers
URN: urn:nbn:se:umu:diva-11484DOI: 10.1016/j.biomaterials.2008.12.008OAI: oai:DiVA.org:umu-11484DiVA: diva2:151155
Available from: 2009-01-22 Created: 2009-01-22 Last updated: 2010-01-27Bibliographically approved

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