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c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat.
Umeå University, Faculty of Medicine, Integrative Medical Biology, Histology and Cell Biology.
2004 (English)In: Brain Research, ISSN 0006-8993, Vol. 1000, no 1-2, 192-4 p.Article in journal (Refereed) Published
Abstract [en]

Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.

Place, publisher, year, edition, pages
2004. Vol. 1000, no 1-2, 192-4 p.
Keyword [en]
Action Potentials/drug effects/*genetics, Anesthesia, Animals, Corpus Striatum/drug effects/*physiology, Genes; fos/drug effects/*genetics, Male, Neurons/drug effects/*physiology, Oligonucleotides; Antisense/*pharmacology, Rats, Rats; Sprague-Dawley
Identifiers
URN: urn:nbn:se:umu:diva-12256DOI: doi:10.1016/j.brainres.2003.10.061PubMedID: 15053967OAI: oai:DiVA.org:umu-12256DiVA: diva2:151927
Available from: 2008-01-11 Created: 2008-01-11 Last updated: 2011-01-12Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15053967&dopt=Citation

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