Short-term plasticity in excitatory synapses of the rat medial preoptic nucleus.
2006 (English)In: Brain Research, ISSN 0006-8993, Vol. 1110, no 1, 128-35 p.Article in journal (Refereed) Published
The medial preoptic nucleus (MPN) regulates sexual behavior which is subject to experience-dependent modifications. Such modifications must depend on functional plasticity in the controlling neural circuits. Thus, MPN synapses are likely candidates for the site of alterations. The present work is a first systematic study of functional synaptic plasticity at glutamatergic synapses in the MPN. Short-term activity-dependent plasticity was investigated using a slice preparation from young male rats. The average efficacy of AMPA/kainate-receptor-mediated synaptic transmission was activity-dependent, showing a peak at a steady stimulation rate of 2 Hz. The variation in efficacy was attributed to mainly presynaptic factors since the average response amplitude was roughly paralleled by the response probability. Upon paired-pulse stimulation, paired-pulse facilitation as well as paired-pulse depression was observed. In some cases, paired-pulse facilitation as well as paired-pulse depression was recorded from an individual neuron depending on the interval between the paired stimuli. On average, paired-pulse facilitation was observed at intervals <500 ms, and paired-pulse depression at intervals in the range 1-4 s. The findings thus reveal complex activity-dependent short-term plasticity of the functional synaptic properties in the medial preoptic nucleus.
Place, publisher, year, edition, pages
2006. Vol. 1110, no 1, 128-35 p.
Animals, Dose-Response Relationship; Radiation, Electric Stimulation/methods, Excitatory Postsynaptic Potentials/*physiology/radiation effects, Neuronal Plasticity/*physiology, Preoptic Area/*cytology, Rats, Rats; Sprague-Dawley, Synapses/*physiology, Time Factors
IdentifiersURN: urn:nbn:se:umu:diva-12593DOI: doi:10.1016/j.brainres.2006.06.061PubMedID: 16870159OAI: oai:DiVA.org:umu-12593DiVA: diva2:152264