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Lighter or heavier than predicted: neural correlates of corrective mechanisms during erroneously programmed lifts
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). (Handkirurgi)
Neuropediatric Unit, Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden / Centre National de la Recherche Scientifique–Groupe Développement et Pathologie de l’Action, Marseilles, France.
Neuropediatric Unit, Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden.
Neuropediatric Unit, Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden / Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, United Kingdom.
2006 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 26, no 35, 9015-9021 p.Article in journal (Refereed) Published
Abstract [en]

A central concept in neuroscience is that the CNS signals the sensory discrepancy between the predicted and actual sensory consequences of action. It has been proposed that the cerebellum and parietal cortex are involved in this process. A discrepancy will trigger preprogrammed corrective responses and update the engaged sensorimotor memories. Here we use functional magnetic resonance imaging with an event-related design to investigate the neuronal correlates of such discrepancies. Healthy adults repeatedly lifted an object between their right index fingers and thumbs, and on some lifting trials, the weight of the object was unpredictably changed between light (230 g) and heavy (830 g). Regardless of whether the weight was heavier or lighter than predicted, activity was found in the right inferior parietal cortex (supramarginal gyrus). This suggests that this region is involved in the comparison of the predicted and actual sensory input and the updating of the sensorimotor memories. When the object was lighter or heavier than predicted, two different types of preprogrammed force corrections occurred. There was a slow force increase when the weight of the object was heavier than predicted. This corrective response was associated with activity in the left primary motor and somatosensory cortices. The fast termination of the excessive force when the object was lighter than predicted activated the right cerebellum. These findings show how the parietal cortex, cerebellum, and motor cortex are involved in the signaling of the discrepancy between predicated and actual sensory feedback and the associated corrective mechanisms.

Place, publisher, year, edition, pages
Bethesda, Md.: Society for Neuroscience , 2006. Vol. 26, no 35, 9015-9021 p.
Keyword [en]
Adult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Motor Cortex/physiology, Parietal Lobe/*physiology, Somatosensory Cortex/physiology, Weight Lifting/*physiology, Weight Perception/*physiology
Identifiers
URN: urn:nbn:se:umu:diva-12637DOI: doi:10.1523/JNEUROSCI.5045-05.2006PubMedID: 16943559OAI: oai:DiVA.org:umu-12637DiVA: diva2:152308
Available from: 2008-01-22 Created: 2008-01-22 Last updated: 2011-03-28Bibliographically approved

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Jenmalm, Per

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