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In vivo recordings of bulbospinal excitation in adult mouse forelimb motoneurons.
Umeå University, Faculty of Medicine, Integrative Medical Biology, Physiology.
2004 (English)In: Journal of Neurophysiology, ISSN 0022-3077, Vol. 92, no 3, 1958-62 p.Article in journal (Refereed) Published
Abstract [en]

Here we report on pyramidal and reticulospinal excitation in forelimb motoneurons in the adult mouse using intracellular recordings in vivo. The results have been obtained in BALB/C mice, which were anesthetized with midazolam fentanyl/fluanison. In contrast to the rat, only weak and infrequent pyramidal excitation could be evoked with a minimal trisynaptic linkage. Disynaptic reticulospinal excitation could always be evoked, as well as monosynaptic excitation from the medial longitudinal fasciculus. The results suggest that the reticulospinal pathway in the mouse is important in voluntary motor control of the forelimbs and that the role of the corticospinal tract might be different in mouse compared with rat. Our study provides an opening for studying the effect of genetic manipulation on specified descending systems in the mouse in vivo.

Place, publisher, year, edition, pages
2004. Vol. 92, no 3, 1958-62 p.
Keyword [en]
Animals, Female, Forelimb/*physiology, Male, Mice, Mice; Inbred BALB C, Motor Neurons/*physiology, Pyramidal Tracts/*physiology, Reticular Formation/physiology
Identifiers
URN: urn:nbn:se:umu:diva-12642DOI: doi:10.1152/jn.00092.2004PubMedID: 15084639OAI: oai:DiVA.org:umu-12642DiVA: diva2:152313
Available from: 2007-11-30 Created: 2007-11-30 Last updated: 2011-01-12Bibliographically approved

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