Change search
ReferencesLink to record
Permanent link

Direct link
Spastic wrist flexors are more severely affected than wrist extensors in children with cerebral palsy.
Umeå University, Faculty of Medicine, Integrative Medical Biology, Anatomy.
2005 (English)In: Developmental Medicine and Child Neurology, ISSN 0012-1622, Vol. 47, no 6, 384-9 p.Article in journal (Refereed) Published
Abstract [en]

Morphological properties of skeletal muscle were compared between wrist flexors and extensors within the same children (n = 8, six females, two males; age range 4 to 9y, median age 7 y) with wrist muscle imbalance secondary to spastic cerebral palsy (CP). Five patients had hemiplegic CP, two diplegic CP, and one patient had tetraplegic CP. Muscle biopsies were taken during either tendon transfer or tendon lengthening procedures. Analyses included distribution of muscle fibre types, fibre sizes, and expression of developmental myosins. Extensor fibre area was significantly greater than flexor fibre area for type 2A fibres and type 2B fibres but not for type 1 fibres. Coefficient of variation (CV) of fibre size for all three fibre types was greater for flexors compared with extensors. The greatest CV was observed for the type 2A fibres in flexors (39.5 [3.6%]). A wide variation was observed for expression of developmental myosin with the magnitude of the expression being greater, but not statistically significant, in flexors compared with extensors (5.4/mm2 vs 0.53/mm2). These data demonstrate that significant secondary myopathy of wrist flexor muscles results from CP.

Place, publisher, year, edition, pages
2005. Vol. 47, no 6, 384-9 p.
Keyword [en]
Age Factors, Analysis of Variance, Biopsy/methods, Cerebral Palsy/*pathology/*physiopathology, Child, Child; Preschool, Female, Humans, Male, Muscle Fibers/pathology, Muscle Spasticity/classification/*pathology/*physiopathology, Muscle; Skeletal/metabolism/*pathology/physiopathology, Myosins/metabolism, Regression Analysis, Wrist/*physiopathology
URN: urn:nbn:se:umu:diva-12679PubMedID: 15938068OAI: diva2:152350
Available from: 2008-01-11 Created: 2008-01-11 Last updated: 2011-01-12Bibliographically approved

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Thornell, Lars-Eric
By organisation

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link