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Remodeling of the innervation of pancreatic islets accompanies insulitis preceding onset of diabetes in the NOD mouse.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
2005 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, Vol. 158, no 1-2, 128-37 p.Article in journal (Refereed) Published
Abstract [en]

The innervation of the islets of Langerhans may constitute a first target for the autoimmunity that develops in type 1 diabetes. Here, we report the occurrence of a decrease in general innervation within the islets in the nonobese diabetic (NOD) mouse, and the establishment of strands of Schwann cells, as detected via p75 and S-100 immunoreactivity (IR), and varicose nerve fibers expressing tyrosine kinase A (TrkA) in association with the immune cells. The findings suggest that there are marked attempts for neurotrophins to promote nerve ingrowth and survival for islet tissue and that remodeling of innervation occurs in the continuation of the insulitis process preceding the onset of type 1 diabetes.

Place, publisher, year, edition, pages
2005. Vol. 158, no 1-2, 128-37 p.
Keyword [en]
Acetylcholinesterase/metabolism, Animals, Animals; Newborn, Diabetes Mellitus; Type 1/metabolism/pathology/*physiopathology, Disease Models; Animal, Female, Immunohistochemistry, Islets of Langerhans/growth & development/*innervation, Mice, Mice; Inbred NOD, Nerve Fibers/metabolism, Oncogene Proteins v-fos/metabolism, Receptor; trkA/metabolism, Receptor; trkB/metabolism, S100 Proteins/metabolism, Ubiquitin Thiolesterase/metabolism
URN: urn:nbn:se:umu:diva-12704DOI: doi:10.1016/j.jneuroim.2004.08.019PubMedID: 15589046OAI: diva2:152375
Available from: 2008-01-11 Created: 2008-01-11 Last updated: 2010-06-24Bibliographically approved

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Persson-Sjögren, SolveigHolmberg, DanForsgren, Sture
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