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Integrin messenger RNAs in the red nucleus after axotomy and neurotrophic administration.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
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2005 (English)In: Neuroreport, ISSN 0959-4965, Vol. 16, no 7, 709-13 p.Article in journal (Refereed) Published
Abstract [en]

Integrins are cell surface receptors known to be important for regeneration in the peripheral nervous system. We have investigated the expression of integrin messenger RNAs in red nucleus neurons of adult rats after axotomy and administration of neurotrophic factors. Using radioactive in situ hybridization, messenger RNA for integrin subunits beta1, alpha3, alpha7 and alphaV could be detected. No change of any alpha subunit could be detected after axotomy. In contrast, a small upregulation of beta1 was detected after lesion. Administration of neurotrophin-3 induced a robust further increase in beta1 messenger RNA levels, whereas brain-derived neurotrophic factor did not. By analogy to the peripheral nervous system, we propose that integrins may be important for a regenerative response in central nervous system neurons.

Place, publisher, year, edition, pages
2005. Vol. 16, no 7, 709-13 p.
Keyword [en]
Animals, Antigens; CD/genetics, Antigens; CD29/*genetics, Autoradiography, Axotomy, Brain-Derived Neurotrophic Factor/pharmacology, Female, In Situ Hybridization, Integrin alpha Chains/genetics, Integrin alpha3/genetics, Integrin alphaV/genetics, Nerve Regeneration/drug effects/*physiology, Neurotrophin 3/pharmacology, RNA; Messenger/analysis, Rats, Rats; Sprague-Dawley, Red Nucleus/*physiology, Spinal Cord Injuries/drug therapy/*physiopathology, Up-Regulation
URN: urn:nbn:se:umu:diva-12708PubMedID: 15858411OAI: diva2:152379
Available from: 2008-01-11 Created: 2008-01-11 Last updated: 2010-06-24Bibliographically approved

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Novikova, LiudmilaNovikov, Lev
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